Correlation between cell-mediated immunity and clinical forms of paracoccidioidomycosis

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dc.contributor.authorMota, N. G S [UNESP]
dc.contributor.authorRezkallah-Iwasso, M. T. [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorAudi, R. C. [UNESP]
dc.contributor.authorMendes, Rinaldo Poncio [UNESP]
dc.contributor.authorMarcondes, J. [UNESP]
dc.contributor.authorMarques, Silvio Alencar [UNESP]
dc.contributor.authorDillon, N. L. [UNESP]
dc.contributor.authorFranco, M. F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T00:26:30Z
dc.date.available2014-05-27T00:26:30Z
dc.date.issued1985-12-01
dc.description.abstractCellular immune response to specific and non-specific stimulants was investigated, both in vivo and in vitro, in 29 healthy controls and in 53 previously untreated patients with the chronic isolated organic form (CIOF), the chronic mixed form (CMF) and the acute progressive form (APF) of paracoccidioidomycosis. The study included skin tests to Paracoccidioides brasiliensis antigen (PbAg) and phytohaemagglutinin (PHA), DNCB sensitization, determination of T lymphocytes and complement rosette-forming cells, lymphocyte transformation and leucocyte migration inhibition tests using PbAg and PHA. Patients displayed staggered cutaneous response to PHA and to PbAg, with marked decrease in intensity in the APF group. DNCB sensitization test and proliferative response of lymphocytes to PHA and PbAg were severely depressed in most of the patients. Leucocyte migration inhibition indices to PbAg were highly positive, while response to PHA was slightly decreased regardless of the clinical form. The number of T lymphocytes was reduced in most of patients and in them the number of complement-rosette forming cells was normal. The distribution of patients according to a suppression index, based in the results of the tests employed, revealed a tendency towards an increased degree of cellular immunosuppression from the least severe (CIOF) to the most severe (APF) clinical form of the disease. On the whole, the present study demonstrated a gamut of immunological reactivity in paracoccidioidomycosis. © 1985.en
dc.description.affiliationDept. of Microbiology and Immunology IBBMA UNESP, 18600 Botucatu, Säo Paulo
dc.description.affiliationDept. of Dermatology and Infectious Disease Faculty of Medicine UNESP, Botucatu, Säo Paulo
dc.description.affiliationUnespDept. of Microbiology and Immunology IBBMA UNESP, 18600 Botucatu, Säo Paulo
dc.description.affiliationUnespDept. of Dermatology and Infectious Disease Faculty of Medicine UNESP, Botucatu, Säo Paulo
dc.format.extent765-772
dc.identifierhttp://dx.doi.org/10.1016/0035-9203(85)90112-9
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene, v. 79, n. 6, p. 765-772, 1985.
dc.identifier.doi10.1016/0035-9203(85)90112-9
dc.identifier.issn0035-9203
dc.identifier.lattes8789480458377552
dc.identifier.lattes6486557387397806
dc.identifier.scopus2-s2.0-0022293843
dc.identifier.urihttp://hdl.handle.net/11449/63724
dc.language.isoeng
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene
dc.relation.ispartofjcr2.820
dc.relation.ispartofsjr1,174
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectfungus antigen
dc.subjectphytohemagglutinin
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectcellular immunity
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunology
dc.subjectleukocyte
dc.subjectleukocyte count
dc.subjectleukocyte migration inhibition test
dc.subjectlymphocyte activation
dc.subjectmale
dc.subjectParacoccidioides
dc.subjectrosette formation
dc.subjectskin test
dc.subjectSouth American blastomycosis
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAntigens, Fungal
dc.subjectCell Migration Inhibition
dc.subjectFemale
dc.subjectHuman
dc.subjectImmunity, Cellular
dc.subjectLeukocyte Count
dc.subjectLeukocytes
dc.subjectLymphocyte Activation
dc.subjectMale
dc.subjectMiddle Age
dc.subjectParacoccidioidomycosis
dc.subjectPhytohemagglutinins
dc.subjectRosette Formation
dc.subjectSkin Tests
dc.subjectSupport, Non-U.S. Gov't
dc.titleCorrelation between cell-mediated immunity and clinical forms of paracoccidioidomycosisen
dc.typeArtigo
dcterms.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
unesp.advisor.lattes6486557387397806
unesp.author.lattes8789480458377552
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB
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