A comparative-analysis of glycosaminoglycans from human umbilical arteries in normal subjects and in pathological conditions affecting pregnancy

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dc.contributor.authorCardoso, L. E. M.
dc.contributor.authorErlich, R. B.
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorPeraçoli, José Carlos [UNESP]
dc.contributor.authorMourao, P. A. S.
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:32Z
dc.date.available2014-05-20T15:22:32Z
dc.date.issued1992-11-01
dc.description.abstractBACKGROUND: Vascular cells express different phenotypes in adult and fetal vessels, and the extracellular matrix they synthesize should reflect these differences. Alterations of vascular proteoglycan/glycosaminoglycan is verified in disorders such as hypertension and diabetes, and when occurring during pregnancy, they bring about structural changes to fetal vessels that often lead to impaired fetus growth. Yet there is little data about the extracellular matrix of an important human fetal vessel, the umbilical artery.EXPERIMENTAL DESIGN: This study involved the biochemical characterization of the extracellular matrix of normal umbilical arteries, umbilical arteries from complicated pregnancies (maternal hypertension and diabetes and intrauterine growth retardation syndrome), and, for purpose of comparison, normal adult arteries (aorta and iliac and pulmonary arteries). Although the collagen types I:III ratio was determined in some cases, emphasis was placed on analysis of glycosaminoglycans.RESULTS: Normal umbilical arteries differ from normal adult arteries in that they contain greater concentrations of hyaluronic acid and lesser concentrations of heparan sulfate and chondroitin 4-and 6-sulfate. The umbilical artery also differs from adult arteries in the disaccharide composition of its chondroitin and heparan sulfates and in the molecular weight of this latter glycosaminoglycan. The glycosaminoglycan distribution in umbilical arteries derived from complicated pregnancies is roughly similar to that of controls. However, total glycosaminoglycan and collagen were significantly reduced, and the collagen I:III ratio was increased in the umbilical arteries from hypertension-complicated pregnancies.CONCLUSIONS: the glycosaminoglycan composition of the normal umbilical artery, a fully differentiated tissue, differs in many aspects from that of normal adult arteries. of the cases of complicated pregnancies studied, the extracellular matrix of umbilical arteries was altered only in maternal hypertension. The changes, notably a mild fibrosis, were not very pronounced and should not impair hemodynamic properties of the vessel.en
dc.description.affiliationUNIV FED RIO DE JANEIRO,INST CIENCIAS BIOMED,DEPT BIOQUIM,CAIXA POSTAL 68041,BR-21910 RIO JANEIRO,BRAZIL
dc.description.affiliationUNIV ESTADUAL JULIO MESQUITA FILHO,FAC MED,DEPT GINECOL & OBSTET,BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL JULIO MESQUITA FILHO,FAC MED,DEPT GINECOL & OBSTET,BOTUCATU,SP,BRAZIL
dc.format.extent588-595
dc.identifier.citationLaboratory Investigation. Baltimore: Williams & Wilkins, v. 67, n. 5, p. 588-595, 1992.
dc.identifier.issn0023-6837
dc.identifier.lattes6758680388835078
dc.identifier.lattes8499437381595614
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.urihttp://hdl.handle.net/11449/33488
dc.identifier.wosWOS:A1992JY31900007
dc.language.isoeng
dc.publisherWilliams & Wilkins
dc.relation.ispartofLaboratory Investigation
dc.relation.ispartofjcr4.254
dc.relation.ispartofsjr1,883
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHYPERTENSION IN PREGNANCYpt
dc.subjectHEPARAN SULFATEpt
dc.subjectCHONDROITIN SULFATEpt
dc.titleA comparative-analysis of glycosaminoglycans from human umbilical arteries in normal subjects and in pathological conditions affecting pregnancyen
dc.typeArtigo
dcterms.licensehttp://www.nature.com/authors/policies/license.html
dcterms.rightsHolderWilliams & Wilkins
unesp.author.lattes6758680388835078
unesp.author.lattes8499437381595614
unesp.author.orcid0000-0002-9227-832X[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Ginecologia e Obstetrícia - FMB