The effect of BMP-2 on the osteoconductive properties of beta-tricalcium phosphate in rat calvaria defects

Página do item simplificado
dc.contributor.authorLuvizuto, Eloa R. [UNESP]
dc.contributor.authorTangl, Stefan
dc.contributor.authorZanoni, Gerald
dc.contributor.authorOkamoto, Tetuo [UNESP]
dc.contributor.authorSonoda, Celso Koogi [UNESP]
dc.contributor.authorGruber, Reinhard
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.institutionMed Univ Vienna
dc.contributor.institutionLudwig Boltzmann Inst Expt & Clin Traumatol
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Sagrado Coração (USC)
dc.date.accessioned2013-09-30T18:29:21Z
dc.date.accessioned2014-05-20T13:43:13Z
dc.date.available2013-09-30T18:29:21Z
dc.date.available2014-05-20T13:43:13Z
dc.date.issued2011-05-01
dc.description.abstractBone formation in critical-sized calvaria defects is strongly dependent on the osteoconductive properties of grafts. It remains a matter of controversy whether biomaterials can replace autografts and whether the supplementation of biomaterials with Bone Morphogenetic Proteins (BMPs) is necessary to enhance bone formation. We examined rat calvaria critical-sized defects (5-mm-diameter) treated with beta-tricalcium phosphate (TCP; Cerasorb (R) M), polylactic and polyglycolic acid gel (PLA/PGA; Fisiograft (R)) and calcium phosphate cement (CPC; Norian (R) CRS (R)), either alone or in the presence of 5 mu g of BMP-2 after 45 days. Autografts and untreated defects served as controls. Bone formation was evaluated based on mu CT analysis, histomorphometric analysis and fluorescence analysis. We report that TCP supported bone formation more efficiently than did autografts. Bone formation in the presence of TCP alone reached a maximal level, as BMP-2 supplementation failed to enhance bone formation. By contrast, no significant difference in bone formation was observed when PLA/PGA and CPC were compared to autografts. Moreover, the presence of BMP-2 did not substantially change the osteoconductive properties of PLA/PGA or CPC. We conclude that the osteoconductive properties of TCP are superior to those of autografts and that TCP does not require BMP-2 supplementation. Our findings also show that the decreased osteoconductive properties of PLA/PGA and CPC cannot be overcome by BMP-2 supplementation in rat calvaria defects. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.affiliationMed Univ Vienna, Dept Oral Surg, A-1090 Vienna, Austria
dc.description.affiliationLudwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria
dc.description.affiliationUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Surg, São Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Integrated Clin, São Paulo, Brazil
dc.description.affiliationUniv Sagrado Coracao, Dept Res & Postgrad, Bauru, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Aracatuba Dent Sch, Integrated Clin, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 08/10516-6
dc.format.extent3855-3861
dc.identifierhttp://dx.doi.org/10.1016/j.biomaterials.2011.01.076
dc.identifier.citationBiomaterials. Oxford: Elsevier B.V., v. 32, n. 15, p. 3855-3861, 2011.
dc.identifier.doi10.1016/j.biomaterials.2011.01.076
dc.identifier.issn0142-9612
dc.identifier.lattes0169955363968097
dc.identifier.lattes5007703439443544
dc.identifier.lattes1566928219828056
dc.identifier.urihttp://hdl.handle.net/11449/15053
dc.identifier.wosWOS:000289610500017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiomaterials
dc.relation.ispartofjcr8.806
dc.relation.ispartofsjr3,111
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAnimal modelen
dc.subjectBone regenerationen
dc.subjectBMP (bone morphogenetic protein)en
dc.subjectCalcium phosphate cementen
dc.subjectPolylactic aciden
dc.subjectBone tissue engineeringen
dc.titleThe effect of BMP-2 on the osteoconductive properties of beta-tricalcium phosphate in rat calvaria defectsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0169955363968097
unesp.author.lattes5007703439443544
unesp.author.lattes1566928219828056
unesp.author.orcid0000-0001-5400-9009[6]
unesp.author.orcid0000-0002-6773-6966[7]
unesp.author.orcid0000-0002-9023-4745[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Cirurgia e Clínica Integrada - FOA