Porous polyethylene for tissue engineering applications in diabetic rats treated with calcitonin: Histomorphometric analysis

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dc.contributor.authorClaro, Flávio Augusto
dc.contributor.authorLima, José Roberto Sá [UNESP]
dc.contributor.authorSalgado, Miguel Angel Castillo [UNESP]
dc.contributor.authorGomes, Mônica Fernandes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:17Z
dc.date.available2014-05-27T11:21:17Z
dc.date.issued2005-03-01
dc.description.abstractPurpose: The purpose of this work was to study the bone tissue reaction after porous polyethylene (Polipore) implantation into surgical defects in the parietal bones of rats with streptozotocin-induced diabetes, treated with salmon calcitonin. Materials and Methods: Porous polyethylene implants were placed in bone defects created in 36 adult female rats. The rats were divided into 3 equal groups: diabetic treated with calcitonin (DCa), diabetic (D), and control (C). The animals of the DCa group received applications of salmon calcitonin on alternating days immediately after the surgery until sacrifice. The rats were sacrificed after 15, 30, 60, and 90 days, and the defects were examined histologically and statistically through histomorphometric analysis. Results: Histomorphometric analysis showed that there was no statistically significant difference in the mean quantity of inflammatory cells among all study groups after 15 and 90 days. At 30 days, a statistically significant difference was observed between the D and C groups and the D and DCa groups. At 60 days, there was no statistically significant difference between the D and DCa groups. Discussion: Porous polyethylene can be considered an option for implant material when there are investigations that prove its biocompatibility and stability in the host tissues. Salmon calcitonin positively aided the bone repair and attenuated the inflammatory response until 30 days after the surgery. Conclusion: Porous polyethylene was tolerated by the host tissues in all groups, and moderate chronic inflammatory reaction was observed up to the 90-day period. Salmon calcitonin attenuated the inflammatory response up until 30 days.en
dc.description.affiliationDept. Oral Maxillofacial Surg., P. S. Jose Dos Campos Sch. of Dent. S. Paulo State University - UNESP, São José dos Campos, SP
dc.description.affiliationDept. of Biosci. and Oral Diagnosis S. Jose Dos Campos Sch. of Dent. S. Paulo State University - UNESP, São José dos Campos, SP
dc.description.affiliationBiosci. Ctr. Spec. Hlth. Care Needs Spec. Health Care Needs Association, São José dos Campos, SP
dc.description.affiliationFaculdade Odontol. S. Jose Dos C. Depto. Biociencias Diagnostico Oral, Av Eng Francisco Jose Longo, 777, São José dos Campos, SP
dc.description.affiliationUnespDept. Oral Maxillofacial Surg., P. S. Jose Dos Campos Sch. of Dent. S. Paulo State University - UNESP, São José dos Campos, SP
dc.description.affiliationUnespDept. of Biosci. and Oral Diagnosis S. Jose Dos Campos Sch. of Dent. S. Paulo State University - UNESP, São José dos Campos, SP
dc.format.extent211-219
dc.identifierhttp://www.quintpub.com/journals/omi/abstract.php?article_id=1697
dc.identifier.citationInternational Journal of Oral and Maxillofacial Implants, v. 20, n. 2, p. 211-219, 2005.
dc.identifier.issn0882-2786
dc.identifier.lattes8235700830441386
dc.identifier.lattes1274225455678400
dc.identifier.scopus2-s2.0-17844362182
dc.identifier.urihttp://hdl.handle.net/11449/68163
dc.identifier.wosWOS:000228312500006
dc.language.isoeng
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Implants
dc.relation.ispartofjcr1.699
dc.relation.ispartofsjr1,576
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBone repair
dc.subjectDiabetes mellitus
dc.subjectPorous polyethylene
dc.subjectSalmon calcitonin
dc.subjectStreptozotocin
dc.subjectpolyethylene
dc.subjectsalcatonin
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbone tissue
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectimplant
dc.subjectimplantation
dc.subjectinflammatory cell
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectporosity
dc.subjectrat
dc.subjectskull defect
dc.subjectstatistical significance
dc.subjectstreptozocin diabetes
dc.subjecttissue engineering
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBone Diseases
dc.subjectBone Substitutes
dc.subjectCalcitonin
dc.subjectConnective Tissue
dc.subjectDiabetes Mellitus, Experimental
dc.subjectFemale
dc.subjectGiant Cells
dc.subjectGranulation Tissue
dc.subjectInjections, Subcutaneous
dc.subjectLymphocytes
dc.subjectMacrophages
dc.subjectParietal Bone
dc.subjectPolyethylene
dc.subjectPorosity
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectStreptozocin
dc.subjectTime Factors
dc.subjectTissue Engineering
dc.subjectWound Healing
dc.titlePorous polyethylene for tissue engineering applications in diabetic rats treated with calcitonin: Histomorphometric analysisen
dc.typeArtigo
dcterms.licensehttp://www.quintpub.com/terms.php
unesp.author.lattes8235700830441386
unesp.author.lattes1274225455678400
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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