Hemoglobin and HFE gene polymorphisms in Brazilian populations in regions endemic for malaria

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dc.contributor.authorTorres, Felipe Rafael
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:10Z
dc.date.available2014-05-20T15:27:10Z
dc.date.issued2006-01-01
dc.description.abstractOur objective was to determine how the distribution of red blood cell diseases is related to malaria occurrence in north Brazil, a region endemic for malaria. We evaluated the incidence of two mutations in the HFE gene, H63D and C282Y, in two study groups: a control blood donor group, with no indication of malaria infection, and a group constituted of malaria patients of four states of the Amazonian region. The hemoglobin polymorphisms were obtained by HPLC and classical laboratory methodologies, and the two mutations in the HFE gene were assayed by PCR-RFLP. We found a high frequency of alpha thalassemia, but there were no significant differences between blood donors and malaria patients. There were also no significant differences in the frequencies of HbA(2); however, the frequency of HbF was significantly different in individuals with malaria from Para and Rondonia. The mean number of reticulocytes was significantly reduced in the blood donors from the northern region, suggesting an adaptive strategy of these populations to parasitic attack by Plasmodium. Most individuals were heterozygous for the H63D allele of the HFE gene in both study groups. In the blood donors group, the greatest frequency of the H63D allele was found in Caucasians of all the states. In the malaria patients group in Rondonia, there was a high frequency of the H63D allele among the non-Caucasians. In the other states, and in the malaria patients group, the H63D allele was the most frequent among the Caucasians. Based on our results, we suggest that the maintenance of polymorphism of the mutations in the gene HFE can be explained by selective factors other than malaria, or it is due to simple allelic oscillation and by the constant gene flow among the populations in Brazil.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Letras & Ciências Exatas, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Letras & Ciências Exatas, Sao Jose do Rio Preto, SP, Brazil
dc.format.extent89-90
dc.identifierhttp://www.geneticsmr.com/articles/246
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 5, n. 1, p. 89-90, 2006.
dc.identifier.fileWOS000203011700012.pdf
dc.identifier.issn1676-5680
dc.identifier.urihttp://hdl.handle.net/11449/37203
dc.identifier.wosWOS:000203011700012
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjecthemoglobin polymorphismpt
dc.subjecthereditary hemochromatosispt
dc.subjectHFE polymorphismpt
dc.subjectallelic frequencypt
dc.subjectmalariapt
dc.titleHemoglobin and HFE gene polymorphisms in Brazilian populations in regions endemic for malariaen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/5
dcterms.rightsHolderFunpec-editora

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