Preliminary X-ray crystallographic studies of a tetrameric phospholipase A(2) formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom

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dc.contributor.authorMarchi-Salvador, D. P. [UNESP]
dc.contributor.authorCorrea, L. C. [UNESP]
dc.contributor.authorSalvador, G. H. M. [UNESP]
dc.contributor.authorMagro, A. J. [UNESP]
dc.contributor.authorOliveira, C. Z.
dc.contributor.authorIulek, J.
dc.contributor.authorSoares, A. M.
dc.contributor.authorFontes, M. R. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)
dc.date.accessioned2014-05-20T13:49:21Z
dc.date.available2014-05-20T13:49:21Z
dc.date.issued2007-12-01
dc.description.abstractCrotoxin B is a basic phospholipase A(2) found in the venom of Crotalus durissus terrificus and is one of the subunits that constitute crotoxin. This heterodimeric toxin, which is the main component of C. d. terrificus venom, is completed by an acidic, nontoxic and non-enzymatic component (crotoxin A) and is involved in important envenomation effects, such as neurological disorders, myotoxicity and renal failure. Although crotoxin was first crystallized in 1938, no crystal structure is currently available for crotoxin, crotoxin A or crotoxin B. In this work, the crystallization, X-ray diffraction data collection to 2.28 angstrom resolution and molecular-replacement solution of a novel tetrameric complex formed by two dimers of crotoxin B isoforms (CB1 and CB2) is presented.en
dc.description.affiliationUNESP, Inst Biociencias, Dept Fis & Biofis, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUSP, FCFRP, Dept Analises Clin Toxicol & Bromatol, Ribeirao Preto, Brazil
dc.description.affiliationUEPG, Dept Quim, Ponta Grossa, PR USA
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Fis & Biofis, BR-18618000 Botucatu, SP, Brazil
dc.format.extent1067-1069
dc.identifierhttp://dx.doi.org/10.1107/S1744309107058563
dc.identifier.citationActa Crystallographica Section F-structural Biology and Crystallization Communications. Oxford: Blackwell Publishing, v. 63, p. 1067-1069, 2007.
dc.identifier.doi10.1107/S1744309107058563
dc.identifier.issn1744-3091
dc.identifier.urihttp://hdl.handle.net/11449/17586
dc.identifier.wosWOS:000251799500020
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofActa Crystallographica Section F: Structural Biology and Crystallization Communications
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titlePreliminary X-ray crystallographic studies of a tetrameric phospholipase A(2) formed by two isoforms of crotoxin B from Crotalus durissus terrificus venomen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
unesp.author.lattes0059017255172730[4]
unesp.author.orcid0000-0002-4634-6221[8]
unesp.author.orcid0000-0002-4253-6992[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Física e Biofísica - IBB