Microspheres of alginate-chitosan containing isoniazid

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dc.contributor.authorLucinda-Silva, R. M.
dc.contributor.authorEvangelista, R. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNIVALI
dc.date.accessioned2014-05-20T15:22:42Z
dc.date.available2014-05-20T15:22:42Z
dc.date.issued2003-01-01
dc.description.abstractIsoniazid was encapsulated into microspheres of alginate-chitosan by means of a complex coacervation method in an emulsion system. Since the encapsulation of isoniazid tends to be limited by its hydrophilic characteristics, this study proposes its microencapsulation by adsorption. The particles were prepared in three steps: (1) preparation of a W/O emulsion; (2) phase separation; and (3) adsorption of the drug. The isolated particles were placed in a solution of the drug under stirring to allow adsorption. The morphology and particle size were analysed by scanning electron microscopy (SEM). The isoniazid content was determined by extraction in 1 m phosphate buffer pH 7.5 under stirring for 4 h. Finally, the samples were filtered and analysed in an UV/VIS spectrophotometer at 260 nm. In vitro release tests were carried out in 0.05 m phosphate buffer pH 7.5. The results showed that microspheres of alginate-chitosan obtained were of spherical shape. The emulsion used for microparticle formation allows the preparation of particles with a narrow size distribution. The adsorption observed is probably of chemical nature, i.e. there is an ionic interaction between the drug and the surface of the particles.en
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Programa Posgrad Ciências Farmaceut, BR-14801902 São Paulo, Brazil
dc.description.affiliationUNIVALI, Curso Farm, NIQFAR, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Programa Posgrad Ciências Farmaceut, BR-14801902 São Paulo, Brazil
dc.format.extent145-152
dc.identifierhttp://dx.doi.org/10.1080/02652040210162621
dc.identifier.citationJournal of Microencapsulation. Abingdon: Taylor & Francis Ltd, v. 20, n. 2, p. 145-152, 2003.
dc.identifier.doi10.1080/02652040210162621
dc.identifier.issn0265-2048
dc.identifier.urihttp://hdl.handle.net/11449/33645
dc.identifier.wosWOS:000180779300001
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Microencapsulation
dc.relation.ispartofjcr1.793
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmicroparticlespt
dc.subjectchitosanpt
dc.subjectalginatept
dc.subjectcomplex coacervationpt
dc.subjectisoniazidpt
dc.titleMicrospheres of alginate-chitosan containing isoniaziden
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd

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