Mutagenicity of Mouriri pusa Gardner and Mouriri elliptica Martius

Página do item simplificado
dc.contributor.authorSantos, F. V. [UNESP]
dc.contributor.authorTubaldini, F. R. [UNESP]
dc.contributor.authorColus, I. M. S.
dc.contributor.authorAndreo, M. A.
dc.contributor.authorBauab, Taís Maria [UNESP]
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-20T13:24:13Z
dc.date.available2014-05-20T13:24:13Z
dc.date.issued2008-08-01
dc.description.abstractMouriri pusa Gardner and Mouriri elliptica Martius are fruit-bearing plants of the Melastomataceae family, popularly known in Brazil as puca-preto or jaboticaba-do-cerrado, and they are used in folk medicine for the treatment of gastric ulcers. In this study, we employ the Ames test to assess the mutagenicity of compounds obtained from the leaves of these species. The methanol extract of the M. pusa was mutagenic to the Salmonella typhimurium strains TA98, TA97a and TA100, with or without metabolic activation. The methanol extract of M. elliptica induced mutagenic activity in TA98 when metabolized with S9 fraction and TA97a with and without S9, but with lower mutagenicity index (MI) and potencies values than those for M. pusa. Enriched fractions of flavonoids and tannins of M. pusa were also evaluated and they demonstrated positive mutagenicity. The highest values of MI and potency were obtained with the flavonoid fraction, which contains large amounts of quercetin, quercetin glycosides and myricetin. These compounds are probably related to the mutagenicity observed in the Ames test. The dichloromethane extract was not mutagenic in any of the test conditions employed. (C) 2008 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUNESP, Araraquara Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Ctr Biol Sci, Dept Gen Biol, Londrina, PR USA
dc.description.affiliationUNESP, Univ Estadual Paulista,Araraquara Inst Chem, Fac Ciencias Farmaceut Araraquara, Eliana Aparecida Varanda Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Araraquara Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Univ Estadual Paulista,Araraquara Inst Chem, Fac Ciencias Farmaceut Araraquara, Eliana Aparecida Varanda Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent2721-2727
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2008.04.028
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 46, n. 8, p. 2721-2727, 2008.
dc.identifier.doi10.1016/j.fct.2008.04.028
dc.identifier.issn0278-6915
dc.identifier.lattes4910754838277580
dc.identifier.lattes2114570774349859
dc.identifier.lattes7501930236496670
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7452
dc.identifier.wosWOS:000258440100017
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMouriri pusaen
dc.subjectMouriri ellipticaen
dc.subjectmelastomaraceaeen
dc.subjectmutagenicityen
dc.subjectAmes testen
dc.subjectmedicinal plantsen
dc.titleMutagenicity of Mouriri pusa Gardner and Mouriri elliptica Martiusen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes4910754838277580
unesp.author.lattes2114570774349859
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0003-0389-1737[1]
unesp.author.orcid0000-0003-3032-2556[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Ciências Biológicas - FCFAR