Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents

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dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorVon Poelhsitz, Gustavo
dc.contributor.authordo Nascimento, Fabio B.
dc.contributor.authorLeite, Sergio R. A. [UNESP]
dc.contributor.authorBatista, Alzir A.
dc.contributor.authorDeflon, Victor M.
dc.contributor.authorSato, Daisy N.
dc.contributor.authorFranzblau, Scott G.
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.contributor.institutionUniv Illinois
dc.date.accessioned2014-05-20T13:24:16Z
dc.date.available2014-05-20T13:24:16Z
dc.date.issued2010-02-01
dc.description.abstractThe synthesis, characterization and the anti-Mycobacterium tuberculosis (MTB) activities of three ruthenium complexes containing the 2-pyridinecarboxylic acid anion (picolinate), with formulae cis-[Ru(pic)(dppm)(2)]PF(6) (1), Cis- [Ru(pic)(dppe)(2)]PF(6) (2) and [Ru(pic)(2)(PPh(3))(2)] (3) [pic = 2-pyridinecarboxylate; dppm = bis(diphenylphosphino)methane: dppe = 1,2-bis(diphenylphosphino)ethane; PPh(3) = triphenylphosphine] are reported in this article. The complexes were characterized by elemental analysis, spectroscopic and electrochemical techniques. Their in vitro anti mycobacterial activity was determinated as the Minimum Inhibitory Concentration (MIC) for MTB cell growth, measured by the REMA method. The best MICs were found for complexes (1) and (2), with values of 0.78 and 0.26 mu g/mL, respectively. The results are comparable to or better than "first line" or "second line" drugs commonly used in the treatment of TB. (C) 2009 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Quim, BR-75704020 Catalao, Go, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13565905 São Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim São Carlos, BR-13566590 São Carlos, SP, Brazil
dc.description.affiliationInst Adolfo Lutz Registro, Unidade Ribeirao Preto, BR-14085410 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCYTED-RIIDFCM
dc.description.sponsorshipIdFAPESP: 08/10390-2
dc.description.sponsorshipIdFAPESP: 09/06499-1
dc.format.extent598-601
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2009.10.049
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 45, n. 2, p. 598-601, 2010.
dc.identifier.doi10.1016/j.ejmech.2009.10.049
dc.identifier.issn0223-5234
dc.identifier.lattes2114570774349859
dc.identifier.urihttp://hdl.handle.net/11449/7480
dc.identifier.wosWOS:000274773300022
dc.language.isoeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.ispartofjcr4.816
dc.relation.ispartofsjr1,266
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAntimycobacterial agentsen
dc.subjectMycobacterium tuberculosisen
dc.subjectREMAen
dc.subjectRuthenium (II) Complexesen
dc.subjectPhosphinesen
dc.subjectPicolinateen
dc.titleRuthenium (II) phosphine/picolinate complexes as antimycobacterial agentsen
dc.typeCarta
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier France-editions Scientifiques Medicales Elsevier
unesp.author.lattes2114570774349859
unesp.author.orcid0000-0002-6969-3963[1]
unesp.author.orcid0000-0003-1329-2260[2]
unesp.author.orcid0000-0002-8698-0243[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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