Diltiazem não induziu crescimento gengival em ratos. Análise clínica, histológica e histométrica

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dc.contributor.authorde Oliveira Bello Corrêa, Fernanda [UNESP]
dc.contributor.authorGiro, Gabriela [UNESP]
dc.contributor.authorGonçalves, Daniela [UNESP]
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.authorOrrico, Silvana Regina Perez [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:22Z
dc.date.available2014-05-27T11:21:22Z
dc.date.issued2005-07-01
dc.description.abstractThe administration of calcium channel blockers has been associated with gingival overgrowth. However, there are few studies in humans or animals that evaluated the effect of diltiazem on gingival tissues. The present study assessed the influence of diltiazem, at different dosages and treatment duration, on gingival tissues of rats, using clinical, histological and histometric analyses. Eighty young male rats were separated into eight groups according to the dosage and duration of treatment. Rats were treated for 20 or 40 days with a daily subcutaneous injection of 5, 20 or 50 mg/kg of body weight of diltiazem. The results confirmed that diltiazem did not induce gingival overgrowth in rats. For all animals, the evaluation did not show gingival alterations regardless of the dosages and periods of treatment. The histometric analysis showed no significant change in the area of epithelium and connective tissues, although after 40 days of treatment a decrease in the area of connective tissue was observed, without statistically significant difference from control groups. Within the limits of this study, we suggest that diltiazem did not induce gingival overgrowth.en
dc.description.affiliationDepartment of Diagnosis and Surgery São Paulo State University
dc.description.affiliationDepartment of Physiology and Pathology São Paulo State University
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University
dc.description.affiliationUnespDepartment of Diagnosis and Surgery São Paulo State University
dc.description.affiliationUnespDepartment of Physiology and Pathology São Paulo State University
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry of Araraquara São Paulo State University
dc.format.extent163-168
dc.identifierhttp://dx.doi.org/10.1590/S1806-83242005000300002
dc.identifier.citationBrazilian Oral Research, v. 19, n. 3, p. 163-168, 2005.
dc.identifier.doi10.1590/S1806-83242005000300002
dc.identifier.file2-s2.0-33747523130.pdf
dc.identifier.issn1806-8324
dc.identifier.issn1807-3107
dc.identifier.lattes2640929291808415
dc.identifier.lattes7383391319292040
dc.identifier.scieloS1806-83242005000300002
dc.identifier.scopus2-s2.0-33747523130
dc.identifier.urihttp://hdl.handle.net/11449/68318
dc.language.isopor
dc.relation.ispartofBrazilian Oral Research
dc.relation.ispartofjcr1.223
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntihypertensive agents
dc.subjectDiltiazem
dc.subjectGingival overgrowth
dc.titleDiltiazem não induziu crescimento gengival em ratos. Análise clínica, histológica e histométricapt
dc.title.alternativeDiltiazem did not induce gingival overgrowth in rats. A clinical, histological and histometric analysisen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bor/iaboutj.htm
unesp.author.lattes2640929291808415
unesp.author.lattes7383391319292040
unesp.author.orcid0000-0002-1987-1207[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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