Alveolar bone dynamics in osteoporotic rats treated with raloxifene or alendronate: confocal microscopy analysis

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dc.contributor.authorRamalho-Ferreira, Gabriel [UNESP]
dc.contributor.authorFaverani, Leonardo Perez [UNESP]
dc.contributor.authorGrossi-Oliveira, Gustavo Augusto [UNESP]
dc.contributor.authorOkamoto, Tetuo [UNESP]
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-21T13:10:16Z
dc.date.available2015-10-21T13:10:16Z
dc.date.issued2015-03-01
dc.description.abstractIn this study, the characteristics of the alveolar bone of rats with induced osteoporosis were examined. Thirty-two rats were divided into four groups according to the induction of osteoporosis and drugs administered: OG, osteoporotic rats without treatment (negative control); SG, rats which underwent sham surgery ovariectomy (SHAM); alendronate (AG), osteoporotic rats treated with alendronate; and RG, osteoporotic rats treated with raloxifene (RG). On the 8th day after ovariectomy and SHAM surgeries, drug therapy was started with AG or RG. On the 52nd day, 20 mg/kg calcein was administered to all of the rats, and on the 80th day, 20 mg/kg alizarin red was administered. Euthanasia was performed on the 98th day. The bone area marked by fluorochromes was calculated and data were subjected to two-way ANOVA test and Tukey's post-hoc test (p < 0.05). The comparison of the induced osteoporosis groups showed no statistically significant differences in bone turnover only between RG and SG (p = 0.074) and AG and OG (p = 0.138). All other comparisons showed significant differences (p < 0.001). The largest bone turnover was observed in RG and SG groups. RG was the medication that improved the dynamics of the alveolar bone of rats with induced osteoporosis, resembling that of healthy rats. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)en
dc.description.affiliationUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Surg, BR-16015050 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Integrated Clin, BR-16015050 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Basic Sci, BR-16015050 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Surg, BR-16015050 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Integrated Clin, BR-16015050 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Basic Sci, BR-16015050 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2010/13971-6
dc.description.sponsorshipIdFAPESP: 2012/15912-2
dc.format.extent7
dc.identifierhttp://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=2213383
dc.identifier.citationJournal Of Biomedical Optics. Bellingham: Spie-soc Photo-optical Instrumentation Engineers, v. 20, n. 3, 7 p., 2015.
dc.identifier.doi10.1117/1.JBO.20.3.038003
dc.identifier.issn1083-3668
dc.identifier.lattes0169955363968097
dc.identifier.lattes1566928219828056
dc.identifier.lattes1527011976590326
dc.identifier.urihttp://hdl.handle.net/11449/128484
dc.identifier.wosWOS:000352272300038
dc.language.isoeng
dc.publisherSpie-soc Photo-optical Instrumentation Engineers
dc.relation.ispartofJournal Of Biomedical Optics
dc.relation.ispartofjcr2.367
dc.relation.ispartofsjr0,918
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectosteoporosisen
dc.subjectalendronateen
dc.subjectraloxifeneen
dc.subjectmicroscopyen
dc.titleAlveolar bone dynamics in osteoporotic rats treated with raloxifene or alendronate: confocal microscopy analysisen
dc.typeArtigo
dcterms.rightsHolderSpie-soc Photo-optical Instrumentation Engineers
unesp.author.lattes0169955363968097
unesp.author.lattes1566928219828056
unesp.author.lattes1527011976590326
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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