Healing at mandibular block-grafted sites: an experimental study in dogs

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dc.contributor.authorDe Santis, Enzo
dc.contributor.authorLang, Niklaus P.
dc.contributor.authorFavero, Giovanni
dc.contributor.authorBeolchini, Marco
dc.contributor.authorMorelli, Fabrizio
dc.contributor.authorBotticelli, Daniele [UNESP]
dc.contributor.institutionARDEC
dc.contributor.institutionUniversidade de Hong Kong
dc.contributor.institutionUniversidade de Zurich
dc.contributor.institutionUniversidade de Medicina Science
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-22T06:46:11Z
dc.date.available2015-10-22T06:46:11Z
dc.date.issued2015-05-01
dc.description.abstractAimThe aim of this study was to evaluate the healing of autologous bone block grafts or deproteinized bovine bone mineral (DBBM) block grafts applied concomitantly with collagen membranes for horizontal alveolar ridge augmentation.Material and methodsIn six Labrador dogs, molars were extracted bilaterally, the buccal bony wall was removed, and a buccal box-shaped defect created. After 3months, a bony block graft was harvested from the right ascending ramus of the mandible and reduced to a standardized size. A DBBM block was tailored to similar dimensions. The two blocks were secured with screws onto the buccal wall of the defects in the right and left sides of the mandible, respectively. Resorbable membranes were applied at both sides, and the flaps sutured. After 3months, one implant was installed in each side of the mandible, in the interface between grafts and parent bone. After 3months, biopsies were harvested and ground sections prepared to reveal a 6-month healing period of the grafts.Results776.2% and 5.9 +/- 7.5% of vital mineralized bone were found at the autologous bone and DBBM block graft sites, respectively. Moreover, at the DBBM site, 63 +/- 11.7% of connective tissue and 31 +/- 15.5% of DBBM occupied the area analyzed. Only 0.2 +/- 0.4% of DBBM was found in contact with newly formed bone. The horizontal loss was in a mean range of 0.9-1.8mm, and 0.3-0.8mm, at the autologous bone and DBBM block graft sites, respectively.ConclusionsAutologous bone grafts were vital and integrated to the parent bone after 6months of healing. In contrast, DBBM grafts were embedded into connective tissue, and only a limited amount of bone was found inside the scaffold of the biomaterial.en
dc.description.affiliationARDEC, Ariminum Odontol, Rimini, Italy
dc.description.affiliationUniv Hong Kong, Prince Philip Dent Hosp, Hong Kong, Hong Kong, Peoples R China
dc.description.affiliationUniv Zurich, Zurich, Switzerland
dc.description.affiliationUniv Med Sci, Fac Dent, Havana, Cuba
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Dent Aracatuba, Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Universidade Estadual Paulista, Faculdade de Odontologia Araçatuba, Sao Paulo, Brazil
dc.description.sponsorshipSweden &Martina SRL, Due Carrare, Padova, Italy
dc.description.sponsorshipARDEC, Ariminum Odontologica SRL, Rimini, Italy
dc.description.sponsorshipClinical Research Foundation (CRF) for the Promotion of Oral Health, Brienz, Switzerland
dc.format.extent516-522
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/clr.12434/full
dc.identifier.citationClinical Oral Implants Research. Hoboken: Wiley-blackwell, v. 26, n. 5, p. 516-522, 2015.
dc.identifier.doi10.1111/clr.12434
dc.identifier.issn0905-7161
dc.identifier.urihttp://hdl.handle.net/11449/129766
dc.identifier.wosWOS:000352562200005
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Oral Implants Research
dc.relation.ispartofjcr4.305
dc.relation.ispartofsjr2,462
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAnimal studyen
dc.subjectBone defectsen
dc.subjectBone graften
dc.subjectBone healingen
dc.subjectBone regenerationen
dc.subjectDeproteinized bovine bone mineralen
dc.subjectHistologyen
dc.titleHealing at mandibular block-grafted sites: an experimental study in dogsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0002-9126-2393[3]
unesp.author.orcid0000-0003-2804-1632[6]

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