Effects and toxicity of Eugenia punicifolia extracts in streptozotocin-diabetic rats

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dc.contributor.authorBrunetti, Iguatemy Lourenço [UNESP]
dc.contributor.authorVendramini, Regina Célia [UNESP]
dc.contributor.authorJanuario, A. H.
dc.contributor.authorFranca, S. C.
dc.contributor.authorPepato, Maria Teresa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ribeirao Preto
dc.date.accessioned2014-05-20T13:24:30Z
dc.date.available2014-05-20T13:24:30Z
dc.date.issued2006-01-01
dc.description.abstractExtracts and decoctions of Eugenia jambolana Lam., Eugenia uniflora L., and Eugenia punicifolia (Humb., Bonpl. & Kunt) DC. are used in traditional medicine to treat diabetes mellitus. Although there have been reports that Eugenia jambolana and Eugenia uniflora have antidiabetic effects, no study has yet been made on Eugenia punicifolia . We investigated the effects of aqueous, butanol, and methanol extracts of Eugenia punicifolia leaves administered by gavage to streptozotocin-diabetic rats for 26 to 29 days. Body weight, food and fluid intake, urine volume, and urinary glucose and urea were evaluated every 7 days. At the end of the experiment, we measured serum cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides and bilirubin, hepatic glycogen and serum marker-enzymes (alanine and aspartate aminotransferases, alkaline phosphatase, gamma-glutamyltransferase, L-lactate dehydrogenase, creatine kinase, alpha-amylase, and angiotensin I converting enzyme). We found that in rats treated with the aqueous extracts, food and liquid intake, urinary volume, and body weight were all reduced, while for rats treated with the methanol extract, not only were liquid intake, urinary volume and body weight reduced, but urinary glucose and urea also decreased. Rats treated with the butanol extract showed no significant alterations in any of the parameters measured. Chronic treatment with extracts had no effect on the marker enzymes nor on serum bilirubin levels. The results indicate that aqueous extracts of Eugenia punicifolia leaves produced an anorexic effect and that methanol extracts had a beneficial effect on the diabetic state by improving carbohydrate and protein metabolism without provoking hepatobiliary, microvascular, muscular, or pancreatic toxic effects.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut Araraquara, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Ribeirao Preto, Unidade Biotecnol Vegetal, Ribeirao Preto, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut Araraquara, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.format.extent35-43
dc.identifierhttp://dx.doi.org/10.1080/13880200500530575
dc.identifier.citationPharmaceutical Biology. Philadelphia: Taylor & Francis Inc., v. 44, n. 1, p. 35-43, 2006.
dc.identifier.doi10.1080/13880200500530575
dc.identifier.issn1388-0209
dc.identifier.lattes7641979287850489
dc.identifier.urihttp://hdl.handle.net/11449/7620
dc.identifier.wosWOS:000235953600008
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofPharmaceutical Biology
dc.relation.ispartofjcr1.918
dc.relation.ispartofsjr0,563
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectantidiabetic activitypt
dc.subjectchronic treatmentpt
dc.subjectEugenia punicifoliapt
dc.subjectmarker enzymespt
dc.subjecttoxicitypt
dc.titleEffects and toxicity of Eugenia punicifolia extracts in streptozotocin-diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.lattes7641979287850489
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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