Mixture of vitamin C, hesperidin and piperidol exposure in pregnancy: Maternal-fetal repercussions

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dc.contributor.authorVolpato, Gustavo Tadeu [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorMiranda, Márcia Regina F. [UNESP]
dc.contributor.authorSabbag Filho, Daher
dc.contributor.authorDe Mattos Paranhos Calderon, Iracema [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de Marília (FAMEMA)
dc.date.accessioned2014-05-27T11:21:47Z
dc.date.available2014-05-27T11:21:47Z
dc.date.issued2006-01-01
dc.description.abstractTo evaluate the reproductive performance and the development of their offspring on rat pregnancy. Wistar pregnant rats were gavaged with 0 mg/kg wb/day (control group, n = 20) and 166.5 mg/kg/day of a mixture of vitamin C, hesperidin and piperidol (experimental group, n = 20) during the organogenic period (from day 5 to 14 of pregnancy; positive vaginal smear = day 0). The female rats were killed on day 21 of pregnancy. The number of implantations, resorptions (dead embryos), and live/dead fetuses were counted for the analysis of the postimplantation loss rates. There was neither alteration in maternal reproductive performance, but it was verified an increase of the number of fetuses presenting dilated urether, hydronephrosis, and reduced ossification of skull due to the treatment of female rats with a mixture of vitamin C, hesperidin and piperidol, these abnormalities were considered transitory and may not interfere on offspring development. It was not verified other type of major malformation neither the appearance of fetuses presenting atrophy of upper limbs that it could be associated to use of this drug.en
dc.description.affiliationDepartment of Gynecology Laboratory of Experimental Research of Gynecology and Obstetrics School of Medicine of Botucatu - São Paulo State University (Unesp), São Paulo
dc.description.affiliationAmbulatory of Clinical Genetic Department of Pediatrics School of Medicine of Marilia - FAMEMA, São Paulo
dc.description.affiliationDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu - UNESP, Distrito de Rubiao Junior, s/n, 18618-000 - Botucatu, SP
dc.description.affiliationUnespDepartment of Gynecology Laboratory of Experimental Research of Gynecology and Obstetrics School of Medicine of Botucatu - São Paulo State University (Unesp), São Paulo
dc.description.affiliationUnespDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu - UNESP, Distrito de Rubiao Junior, s/n, 18618-000 - Botucatu, SP
dc.format.extent77-82
dc.identifierhttp://dx.doi.org/10.1590/S1516-93322006000100008
dc.identifier.citationRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences, v. 42, n. 1, p. 77-82, 2006.
dc.identifier.doi10.1590/S1516-93322006000100008
dc.identifier.file2-s2.0-33745912795.pdf
dc.identifier.issn1516-9332
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.scieloS1516-93322006000100008
dc.identifier.scopus2-s2.0-33745912795
dc.identifier.urihttp://hdl.handle.net/11449/68722
dc.language.isoeng
dc.relation.ispartofRevista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHesperidin and piperidol mixture
dc.subjectMaternal repercussions
dc.subjectPregnancy
dc.subjectRats
dc.subjectVitamin C
dc.subjectascorbic acid
dc.subjecthesperidin
dc.subjectpiperidine derivative
dc.subjectanimal experiment
dc.subjectatrophy
dc.subjectbladder sphincter
dc.subjectcontrolled study
dc.subjectembryo resorption
dc.subjectfemale
dc.subjectfetus death
dc.subjectfetus malformation
dc.subjecthydronephrosis
dc.subjectnonhuman
dc.subjectorganogenesis
dc.subjectossification
dc.subjectpercussion
dc.subjectpregnancy
dc.subjectprenatal drug exposure
dc.subjectprogeny
dc.subjectrat
dc.subjectsexual behavior
dc.subjectvagina smear
dc.titleMixture of vitamin C, hesperidin and piperidol exposure in pregnancy: Maternal-fetal repercussionsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rbcf/paboutj.htm
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0002-9227-832X[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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