Antithrombotic effect of Lonomia obliqua caterpillar bristle extract on experimental venous thrombosis

Página do item simplificado
dc.contributor.authorPrezoto, B.C.
dc.contributor.authorMaffei, Francisco Humberto de Abreu [UNESP]
dc.contributor.authorMattar, L. [UNESP]
dc.contributor.authorChudzinski-Tavassi, A.M.
dc.contributor.authorCuri, P.R. [UNESP]
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:32:49Z
dc.date.available2014-05-20T13:32:49Z
dc.date.issued2002-06-01
dc.description.abstractThe venom of Lonomia obliqua caterpillar may induce a hemorrhagic syndrome in humans, and blood incoagulability by afibrinogenemia when intravenously injected in laboratory animals. The possible antithrombotic and thrombolytic activities of L. obliqua caterpillar bristle extract (LOCBE) were evaluated in this study. The minimal intravenous dose of the extract necessary to induce afibrinogenemia and anticoagulation was 3.0 and 10.0 µg protein/kg body weight for rabbits and rats, respectively. In rabbits, this dose induced total blood incoagulability for at least 10 h and did not reduce the weight of preformed venous thrombi, in contrast to streptokinase (30,000 IU/kg). In rats, pretreatment with 5.0 and 10.0 µg/kg LOCBE prevented the formation of thrombi induced by venous stasis or by injury to the venous endothelium. The dose of 5.0 µg/kg LOCBE did not modify blood coagulation assay parameters but increased bleeding time and decreased plasma factor XIII concentration. When the extract was administered to rats at the dose of 10.0 µg/kg, the blood was totally incoagulable for 6 h. These data show that LOCBE was effective in preventing experimental venous thrombosis in rats, justifying further studies using purified fractions of the extract to clarify the mechanisms of this effect.en
dc.description.affiliationInstituto Butantan Laboratório de Farmacologia
dc.description.affiliationInstituto Butantan Laboratório de Bioquímica e Biofísica
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Cirurgia e Ortopedia
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Cirurgia e Ortopedia
dc.format.extent703-712
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2002000600011
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 6, p. 703-712, 2002.
dc.identifier.doi10.1590/S0100-879X2002000600011
dc.identifier.fileS0100-879X2002000600011.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2002000600011
dc.identifier.urihttp://hdl.handle.net/11449/11208
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectThrombosisen
dc.subjectFibrinolysisen
dc.subjectAnticoagulanten
dc.subjectVenomen
dc.subjectLonomia obliqua caterpillaren
dc.titleAntithrombotic effect of Lonomia obliqua caterpillar bristle extract on experimental venous thrombosisen
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0100-879X2002000600011.pdf
Tamanho:
55.26 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Cirurgia e Ortopedia - FMB