ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus

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dc.contributor.authorDe Mattos, Luiz Carlos
dc.contributor.authorCintra, Juliana Rodrigues
dc.contributor.authorSanches, Fábio Eduardo
dc.contributor.authorAlves Da Silva, Rta de Cássia Martins
dc.contributor.authorRuiz, Milton Artur
dc.contributor.authorMoreira, Haroldo Wilson [UNESP]
dc.contributor.institutionFaculty of Medicine of São José do Rio Preto
dc.contributor.institutionHemocenter of São José do Rio Preto
dc.contributor.institutionFUNFARME
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.date.accessioned2014-05-27T11:20:25Z
dc.date.available2014-05-27T11:20:25Z
dc.date.issued2002-03-01
dc.description.abstractCONTEXT: Epidemiological studies have demonstrated higher frequencies of the O blood group and the non-secretor phenotype of ABH antigens among patients suffering from peptic ulcers. Since Helicobacter pylori has been established as the main etiological factor in this disease, controversies about the associations of the ABO and Lewis blood group phenotypes and secretor and non-secretor phenotypes in relation to susceptibility towards infection by this bacillus have been presented. OBJECTIVE: To verify the frequencies of ABO, Lewis blood group phenotypes, secretor and non-secretor phenotypes in patients infected or uninfected by H. pylori. DESIGN: Cross-sectional study. SETTING: Outpatient clinic. PARTICIPANTS: One hundred and twenty patients with dyspeptic symptoms who underwent endoscopy. MAIN MEASUREMENTS: ABO and Lewis blood group phenotypes were determined by a standard hemagglutination test and the secretor and non-secretor phenotypes were evaluated by saliva samples using the inhibitor hemagglutination test. RESULTS: The diagnosis of infection, made via breath and urea tests and confirmed using polymerase chain reaction (PCR) in gastric biopsy fragments, showed the presence of H. pylori in 61.7% of the patients and absence in 38.3%. The differences between the frequencies of the ABO blood group phenotypes among infected (A 27.0%; B 12.2%; AB 4.0% and O 56.8%) and uninfected patients (A 58.7%; B 13.0%; AB 4.3% and O 24.0%) were significant. The Lewis blood type, secretor and non-secretor phenotypes showed homogeneous distribution between the groups of patients analyzed. CONCLUSIONS: Our results suggest that the infection of H. pylori can be related to ABO blood groups but not to the Lewis blood group nor to secretor and non-secretor phenotypes. Copyright©2002, Associação Paulista de Medicina.en
dc.description.affiliationDepartment of Molecular Biology Faculty of Medicine of São José do Rio Preto, S. José do Rio Preto, SP
dc.description.affiliationDepartment of Molecular Biology Faculty of Medicine of São José do Rio Preto
dc.description.affiliationMolecular Immunogenetic Laboratory Hemocenter of São José do Rio Preto, São José do Rio Preto
dc.description.affiliationDepartment of Internal Medicine Faculty of Medicine of São José do Rio Preto
dc.description.affiliationGastroenterology Laboratory Hospital of Base FUNFARME, São José do Rio Preto
dc.description.affiliationBone Marrow Transplant Unit Hospital of Base FUNFARME, São José do Rio Preto
dc.description.affiliationDepartment of Clinical Analyses Faculty of Pharmaceutical Sciences São Paulo State University, São Paulo
dc.description.affiliationDepartamento de Biologia Molecular Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, S. J. do R. Preto/SP - CEP 15090-000
dc.description.affiliationUnespDepartment of Clinical Analyses Faculty of Pharmaceutical Sciences São Paulo State University, São Paulo
dc.format.extent55-58
dc.identifierhttp://dx.doi.org/10.1590/S1516-31802002000200006
dc.identifier.citationSao Paulo Medical Journal, v. 120, n. 2, p. 55-58, 2002.
dc.identifier.doi10.1590/S1516-31802002000200006
dc.identifier.file2-s2.0-0037034506.pdf
dc.identifier.issn1516-3180
dc.identifier.scieloS1516-31802002000200006
dc.identifier.scopus2-s2.0-0037034506
dc.identifier.urihttp://hdl.handle.net/11449/66840
dc.language.isoeng
dc.relation.ispartofSão Paulo Medical Journal
dc.relation.ispartofjcr1.063
dc.relation.ispartofsjr0,334
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectABO
dc.subjectBlood groups
dc.subjectHelicobacter pylori
dc.subjectLewis
dc.subjectNon-secretor phenotype
dc.subjectSecretor phenotype
dc.subjectbacterial infection
dc.subjectblood group ABO system
dc.subjectblood group Lewis system
dc.subjectcontrolled study
dc.subjectdyspepsia
dc.subjectendoscopy
dc.subjecthemagglutination test
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectoutpatient department
dc.subjectphenotype
dc.subjectpolymerase chain reaction
dc.subjectsaliva
dc.subjectstomach biopsy
dc.subjecturea breath test
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectblood
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjectHelicobacter infection
dc.subjectmale
dc.subjectmicrobiology
dc.subjectABO Blood-Group System
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectCross-Sectional Studies
dc.subjectDyspepsia
dc.subjectFemale
dc.subjectHelicobacter Infections
dc.subjectHemagglutination Tests
dc.subjectHumans
dc.subjectLewis Blood-Group System
dc.subjectMale
dc.subjectPhenotype
dc.subjectPolymerase Chain Reaction
dc.titleABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillusen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/spmj/paboutj.htm#03
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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