Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C-2,N-dmba)(Br)(tu)] (dmba = N,N-dimethylbenzylamine, tu = thiourea)

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dc.contributor.authorMoro, Antonio C. [UNESP]
dc.contributor.authorMauro, Antonio Eduardo [UNESP]
dc.contributor.authorNetto, Adelino Vieira de Godoy [UNESP]
dc.contributor.authorAnanias, Sandra R. [UNESP]
dc.contributor.authorQuilles, Marcela B. [UNESP]
dc.contributor.authorCarlos, Iracilda Z. [UNESP]
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.authorLeite, Clarice Q. F. [UNESP]
dc.contributor.authorHoerner, Manfredo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Santa Maria (UFSM)
dc.date.accessioned2014-05-20T13:23:57Z
dc.date.available2014-05-20T13:23:57Z
dc.date.issued2009-11-01
dc.description.abstractThe reactions between [Pd(C-2,N-dmba)(mu-X)](2) (dmba = N,N-dimethylbenzylamine: X = Cl, Br) and thiourea (tu) in the 1:2 molar ratio at room temperature resulted in the mononuclear compounds [Pd(C-2,N-dmba)(Cl)(tu)] (1) and [Pd(C-2,N-dmba)(Br)(tu)] (2), which were characterized by elemental analyses and infrared (IR), H-1- and C-13{H-1} NMR spectroscopies. The crystal and molecular structures of 2 were determined by single-crystal X-ray diffraction. In vitro cytotoxicity assays of the compounds 1, 2, tu, dmba and cisplatin were carried out using two murine tumor cell lines, namely mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). The compounds 1, 2, tu and dmba were also tested against Mycobacterium tuberculosis and their MIC values were determined. (C) 2009 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de Santa Maria (UFSM), Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent4611-4615
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2009.06.032
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 44, n. 11, p. 4611-4615, 2009.
dc.identifier.doi10.1016/j.ejmech.2009.06.032
dc.identifier.issn0223-5234
dc.identifier.lattes3300223970814448
dc.identifier.lattes7927677053650819
dc.identifier.orcid0000-0002-0057-7964
dc.identifier.urihttp://hdl.handle.net/11449/7324
dc.identifier.wosWOS:000271225800041
dc.language.isoeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.ispartofjcr4.816
dc.relation.ispartofsjr1,266
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCyclopalladated complexen
dc.subjectCrystal structureen
dc.subjectcytotoxicity assaysen
dc.subjectMycobacterium tuberculosisen
dc.subjectAntitumoren
dc.subjectThioureaen
dc.titleAntitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C-2,N-dmba)(Br)(tu)] (dmba = N,N-dimethylbenzylamine, tu = thiourea)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier France-editions Scientifiques Medicales Elsevier
unesp.author.lattes3300223970814448[2]
unesp.author.lattes7927677053650819[3]
unesp.author.orcid0000-0002-0057-7964[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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