Synthesis, X-ray structure and antimycobacterial activity of silver complexes with alpha-hydroxycarboxylic acids

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dc.contributor.authorCuin, Alexandre
dc.contributor.authorMassabni, Antonio Carlos [UNESP]
dc.contributor.authorLeite, Clarice Q. F.
dc.contributor.authorSato, Daisy N.
dc.contributor.authorNeves, Ademir
dc.contributor.authorSzpoganicz, Bruno
dc.contributor.authorSilva, Marlon S.
dc.contributor.authorBortoluzzi, Adailton J.
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.date.accessioned2014-05-20T13:24:31Z
dc.date.available2014-05-20T13:24:31Z
dc.date.issued2007-02-01
dc.description.abstractIn this paper, synthesis, characterization and antimycobacterial properties of a new water-soluble complex identified as silver-mandelate are described. Elemental and thermal analyses are consistent with the formula [Ag(C6H5C(OH)COO)](n). The polymeric structure was determined by single X-ray diffraction and the two-dimensional structure is based on the bis(carboxylate-O,O') dimer [Ag-O, 2.237(3), 2.222(3) angstrom]. The structure is extended along both the b and c axes through two oxygen atoms of a bidentate alpha-hydroxyl-carboxylate residue [Ag-OH(hydroxyl), 2.477(3) angstrom; Ag-O(carboxylate), 2.502(3) angstrom; O-Ag-O, 63.94(9)degrees]. A strong d(10)-d(10) interaction was observed between two silver atoms. The Ag...Ag distance is 2.8307(15) angstrom. The NMR C-13 spectrum in D2O shows that coordination of the ligand to Ag(l) occurs through the carboxylate group in solution. Potentiometric titration shows that only species with a molar metaHigand ratio of 2:2 are formed in aqueous solution. The mandelate complex and the silver-glycolate, silver-malate and silver-hydrogen-tartarate complexes were tested against three types of mycobacteria, Mycobacterium avium, Mycobacterium tuberculosis and Mycobacterium kansasii, and their minimal inhibitory concentration (MIC) values were determined. The results show that the four complexes are potential candidates for antiseptic or disinfectant drugs for discharged secretions of patients affected with tuberculosis. (c) 2006 Published by Elsevier B.V.en
dc.description.affiliationUniv Fed Santa Catarina, Lab Bioinorgan & Cristalog, Dept Quim, BR-88040900 Florianopolis, SC, Brazil
dc.description.affiliationUNESP, Dept Quim Geral & Inorgan, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Dept Ciências Ecol, Fac Ciências Farmaceut, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationInst Adolfo Lutz Registro, Lab Ribeirao Preto, BR-14085410 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Quim Geral & Inorgan, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Ciências Ecol, Fac Ciências Farmaceut, BR-14801970 Araraquara, SP, Brazil
dc.format.extent291-296
dc.identifierhttp://dx.doi.org/10.1016/j.jinorgbio.2006.10.001
dc.identifier.citationJournal of Inorganic Biochemistry. New York: Elsevier B.V., v. 101, n. 2, p. 291-296, 2007.
dc.identifier.doi10.1016/j.jinorgbio.2006.10.001
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/11449/7629
dc.identifier.wosWOS:000244191400013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Inorganic Biochemistry
dc.relation.ispartofjcr3.063
dc.relation.ispartofsjr0,743
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsilverpt
dc.subjectmycobacteriapt
dc.subjectalpha-hydroxycarboxylic acidspt
dc.subjectO-donor ligandspt
dc.titleSynthesis, X-ray structure and antimycobacterial activity of silver complexes with alpha-hydroxycarboxylic acidsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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