Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode

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dc.contributor.authorSantos, André L. [UNESP]
dc.contributor.authorTakeuchi, Regina M. [UNESP]
dc.contributor.authorMariotti, Marcela P. [UNESP]
dc.contributor.authorDe Oliveira, Marcelo F. [UNESP]
dc.contributor.authorZanoni, Maria Valnice Boldrin [UNESP]
dc.contributor.authorStradiotto, Nelson Ramos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:23Z
dc.date.available2014-05-27T11:21:23Z
dc.date.issued2005-08-01
dc.description.abstractIn this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E 1/2 = 0.99:V vs. Ag/AgCl sat, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51 ± 0.07) ± 10 -5:cm:s -1, with a αn a value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 ± 10 -5 to 1.0 ± 10 -2:mol:l -1 range, being obtained a detection limit of 2.4 ± 10 -5:mol:l -1. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations. © 2005 Elsevier SAS. All rights reserved.en
dc.description.affiliationDepartamento de Química Analítica Instituto de Química UNESP, Av. Prof. Francisco Degni s/n, CEP 14800-900, Araraquara, SP
dc.description.affiliationUnespDepartamento de Química Analítica Instituto de Química UNESP, Av. Prof. Francisco Degni s/n, CEP 14800-900, Araraquara, SP
dc.format.extent671-674
dc.identifierhttp://dx.doi.org/10.1016/j.farmac.2005.05.004
dc.identifier.citationFarmaco, v. 60, n. 8, p. 671-674, 2005.
dc.identifier.doi10.1016/j.farmac.2005.05.004
dc.identifier.issn0014-827X
dc.identifier.lattes0072173018005712
dc.identifier.orcid0000-0002-2296-1393
dc.identifier.scopus2-s2.0-23944490176
dc.identifier.urihttp://hdl.handle.net/11449/68350
dc.language.isoeng
dc.relation.ispartofFarmaco
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAlbendazole
dc.subjectGlassy carbon
dc.subjectRotating disk electrode
dc.subjectVoltammetric determination
dc.subjectalbendazole
dc.subjectcarbon
dc.subjectsilver chloride
dc.subjectdrug formulation
dc.subjectelectrochemical analysis
dc.subjectelectrode
dc.subjectkinetics
dc.subjectmethodology
dc.subjectoxidation
dc.subjectpotentiometry
dc.subjectCarbon
dc.subjectElectrochemistry
dc.subjectElectrodes
dc.subjectGlass
dc.subjectOxidation-Reduction
dc.subjectPharmaceutical Preparations
dc.subjectRotation
dc.titleStudy of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrodeen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes0072173018005712
unesp.author.orcid0000-0002-2296-1393[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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