Morphological changes in the fast vs slow fiber profiles of the urethras of diabetic pregnant rats

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dc.contributor.authorMarini, Gabriela [UNESP]
dc.contributor.authorBarbosa, Angélica M. Pascon [UNESP]
dc.contributor.authorDamasceno, Débora Cristina [UNESP]
dc.contributor.authorMatheus, Selma Maria Michelin [UNESP]
dc.contributor.authorCastro, Rodrigo de Aquino
dc.contributor.authorGirão, Manoel João B. Castello
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-05-27T11:26:17Z
dc.date.available2014-05-27T11:26:17Z
dc.date.issued2011-12-01
dc.description.abstractBackground: This study was undertaken to test the hypothesis that diabetes and pregnancy detrimentally affect the normal function of urethral striated muscles in rats, providing a model for additional studies related to urinary incontinence. The aim of this study was to evaluate morphological alterations in the urethral striated muscles of diabetic pregnant rats. Materials and Methods: Twenty female Wistar rats were distributed into four experimental groups of five rats as follows: virgin, pregnant, diabetic virgin, and diabetic pregnant. Diabetes was induced using streptozotocin administration (40 mg/kg i.v.). The rats were lethally anesthetized, and the urethra and vagina were extracted as a unit. Cryostat sections (6 μm thick) were cut and stained with hematoxylin-eosin, and immunohistochemical procedures were performed and subjected to morphological and semi quantitative analysis. Results: The urethral striated muscle from the diabetic pregnant rats presented with the following variations: thinning and atrophy, disorganization and disruption associated with the colocalization of fast and slow fibers and a steady decrease in the proportion of fast vs slow fibers. Conclusion: Diabetes and pregnancy impair the urethral striated muscle and alter its fiber type distribution. © Copyright G. Marini et al., 2011.en
dc.description.affiliationExperimental Research Laboratory Department of Gynecology and Obstetrics UNESP - Univ. Estadual Paulista, São Paulo
dc.description.affiliationDepartment of Anatomy Botucatu Biosciences Institute UNESP - Univ. Estadual Paulista, São Paulo
dc.description.affiliationDepartment of Gynecology São Paulo Federal University (UNIFESP), São Paulo
dc.description.affiliationUnespExperimental Research Laboratory Department of Gynecology and Obstetrics UNESP - Univ. Estadual Paulista, São Paulo
dc.description.affiliationUnespDepartment of Anatomy Botucatu Biosciences Institute UNESP - Univ. Estadual Paulista, São Paulo
dc.identifierhttp://dx.doi.org/10.4081/uij.2011.e9
dc.identifierhttp://www.urogynaecologia.org/index.php/uij/article/view/uij.2011.e9
dc.identifier.citationUrogynaecologia International Journal, v. 25, n. 1, 2011.
dc.identifier.doi10.4081/uij.2011.e9
dc.identifier.issn1121-3086
dc.identifier.lattes6758680388835078
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.scopus2-s2.0-84857228590
dc.identifier.urihttp://hdl.handle.net/11449/72960
dc.language.isoeng
dc.relation.ispartofUrogynaecologia International Journal
dc.relation.ispartofsjr0,122
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDiabetes
dc.subjectPregnancy
dc.subjectStriated muscle fiber
dc.subjectUrethra
dc.titleMorphological changes in the fast vs slow fiber profiles of the urethras of diabetic pregnant ratsen
dc.typeArtigo
dcterms.licensehttp://uij.pagepress.org/index.php/uij/about/editorialPolicies#openAccessPolicy
unesp.author.lattes6758680388835078
unesp.author.lattes2604323526583616[2]
unesp.author.orcid0000-0002-9227-832X[7]
unesp.author.orcid0000-0003-0817-9511[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Anatomia - IBB
Artigos - Ginecologia e Obstetrícia - FMB