Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

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dc.contributor.authorFioretto, JR
dc.contributor.authorQuerioz, S. S.
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:22:18Z
dc.date.available2014-05-20T15:22:18Z
dc.date.issued2002-04-01
dc.description.abstractThe effects of protein-calorie malnutrition (PCM) on heart structure and function are not completely understood. We studied heart morphometric, functional, and biochemical characteristics in undernourished young Wistar rats. They were submitted to PCM from birth (undernourished group, UG). After 10 wk, left ventricle function was studied using a Langendorff preparation. The results were compared with age-matched rats fed ad libitum (control group, CG). The UG rats achieved 47% of the body weight and 44% of the left ventricular weight (LVW) of the CG. LVW-to-ventricular volume ratio was smaller and myocardial hydroxyproline concentration was higher in the UG. Left ventricular systolic function was not affected by the PCM protocol. The myocardial stiffness constant was greater in the UG, whereas the end-diastolic pressure-volume relationship was not altered. In conclusion, the heart is not spared from the adverse effects of PCM. There is a geometric alteration in the left ventricle with preserved ventricular compliance despite the increased passive myocardial stiffness. The systolic function is preserved.en
dc.description.affiliationSão Paulo State Univ, Botucatu Med Sch, Dept Pediat, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu Med Sch, Dept Biostat, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Med Sch, Dept Pediat, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Med Sch, Dept Biostat, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP, Brazil
dc.format.extentH1327-H1333
dc.identifierhttp://ajpheart.physiology.org/content/282/4/H1327
dc.identifier.citationAmerican Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 282, n. 4, p. H1327-H1333, 2002.
dc.identifier.doi10.1152/ajpheart.00431.2001
dc.identifier.issn0363-6135
dc.identifier.lattes6990977122340795
dc.identifier.lattes8727897080522289
dc.identifier.lattes6309835137998766
dc.identifier.lattes1590971576309420
dc.identifier.urihttp://hdl.handle.net/11449/33309
dc.identifier.wosWOS:000174365800020
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology-heart and Circulatory Physiology
dc.relation.ispartofjcr3.569
dc.relation.ispartofsjr1,610
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectleft ventricular functionpt
dc.subjectLangendorff preparationpt
dc.subjectisolated heartpt
dc.titleVentricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutritionen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
unesp.author.lattes6990977122340795
unesp.author.lattes8727897080522289[3]
unesp.author.lattes6309835137998766
unesp.author.lattes1590971576309420
unesp.author.orcid0000-0001-8980-8839[5]
unesp.author.orcid0000-0002-7719-9682[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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