Reactivity of mesenteric and aortic rings from trained rats fed with high caloric diet

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dc.contributor.authorde Moraes, Camila
dc.contributor.authorCamargo, Enilton A.
dc.contributor.authorAntunes, Edson
dc.contributor.authorde Nucci, Gilberto
dc.contributor.authorZanesco, Angelina
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-02-26T17:29:51Z
dc.date.accessioned2014-05-20T13:57:54Z
dc.date.available2014-02-26T17:29:51Z
dc.date.available2014-05-20T13:57:54Z
dc.date.issued2007-07-01
dc.description.abstractA strong association between the benefits of physical exercise on the cardiovascular disease with an improvement of the endothelium-derived relaxing factor production has been consistently shown. The purpose of this study was to evaluate the effect of exercise training associated with high caloric diet in the reactivity of rat mesenteric and aortic rings. Experimental protocol consisted of 4 weeks of high caloric diet consumption previous to 4 weeks of run training (1.2 km/h, 0% grade, in sessions of 60 min, 5 days/week). Concentrations of triglycerides, glucose, insulin and nitrite/nitrate levels were measured and atherogenic index was calculated. Concentration-response curves to acetylcholine (10 nM-100 mu M), sodium nitroprusside (100 pM-100 nM) and phenylephrine (1 nM-3 mu M) were obtained. Exercise training reduced body mass (6%) and triglyceride levels (about 54%), without changes in glucose and insulin concentrations. An improvement of endothelium-dependent relaxation responses to acetylcholine in mesenteric and aortic rings was observed in trained group. No changes were seen for sodium nitroprusside and phenylephrine. In conclusion, our study is the first to show clearly that run training promotes an improvement of the endothelium-dependent relaxing response in aorta and mesenteric rings from rats fed with high caloric diet and that is associated with increase of NO production. (c) 2006 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Pharmacol, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.format.extent788-792
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2006.10.018
dc.identifier.citationComparative Biochemistry and Physiology A-molecular & Integrative Physiology. New York: Elsevier B.V., v. 147, n. 3, p. 788-792, 2007.
dc.identifier.doi10.1016/j.cbpa.2006.10.018
dc.identifier.issn1095-6433
dc.identifier.lattes4472007237545596
dc.identifier.urihttp://hdl.handle.net/11449/20627
dc.identifier.wosWOS:000247360500022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Biochemistry and Physiology A-molecular & Integrative Physiology
dc.relation.ispartofjcr2.258
dc.relation.ispartofsjr0,836
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectexercise trainingpt
dc.subjecthigh caloric dietpt
dc.subjectvascular reactivitypt
dc.subjectmesentericpt
dc.subjectaortapt
dc.subjectnitric oxidept
dc.subjectendotheliumpt
dc.titleReactivity of mesenteric and aortic rings from trained rats fed with high caloric dieten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4472007237545596
unesp.author.orcid0000-0002-4346-7941[4]
unesp.author.orcid0000-0003-3735-1165[1]
unesp.author.orcid0000-0003-2201-8247[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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