Antiviral Activity of Quercetin Hydrate against Zika Virus
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Data
2023-04-01
Autores
Saivish, Marielena Vogel
Menezes, Gabriela de Lima
da Silva, Roosevelt Alves
Fontoura, Marina Alves
Shimizu, Jacqueline Farinha
da Silva, Gislaine Celestino Dutra
Teixeira, Igor da Silva
Mistrão, Natalia Franco Bueno
Hernandes, Victor Miranda
Rahal, Paula [UNESP]
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Zika virus (ZIKV) has re-emerged in recent decades, leading to outbreaks of Zika fever in Africa, Asia, and Central and South America. Despite its drastic re-emergence and clinical impact, no vaccines or antiviral compounds are available to prevent or control ZIKV infection. This study evaluated the potential antiviral activity of quercetin hydrate against ZIKV infection and demonstrated that this substance inhibits virus particle production in A549 and Vero cells under different treatment conditions. In vitro antiviral activity was long-lasting (still observed 72 h post-infection), suggesting that quercetin hydrate affects multiple rounds of ZIKV replication. Molecular docking indicates that quercetin hydrate can efficiently interact with the specific allosteric binding site cavity of the NS2B-NS3 proteases and NS1-dimer. These results identify quercetin as a potential compound to combat ZIKV infection in vitro.
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antiviral activity, in silico analysis, inhibition, natural products, Zika virus
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International Journal of Molecular Sciences, v. 24, n. 8, 2023.