Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer

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dc.contributor.authorOliveira Alves, Monica Ghislaine [UNESP]
dc.contributor.authorDelgado, Adriana da Mota [UNESP]
dc.contributor.authorBalducci, Ivan [UNESP]
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.authorRodrigues Cavalcante, Ana Sueli [UNESP]
dc.contributor.authorAlmeida, Janete Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:52:59Z
dc.date.available2015-03-18T15:52:59Z
dc.date.issued2014-11-01
dc.description.abstractActinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal-Wallis and Dunn's tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3-1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3-1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Sci & Technol, Dept Social Sci & Pediat Dent, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Sci & Technol, Dept Social Sci & Pediat Dent, UNESP, BR-12245000 Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent837-841
dc.identifierhttp://dx.doi.org/10.1007/s00403-014-1500-8
dc.identifier.citationArchives Of Dermatological Research. New York: Springer, v. 306, n. 9, p. 837-841, 2014.
dc.identifier.doi10.1007/s00403-014-1500-8
dc.identifier.issn0340-3696
dc.identifier.lattes6967369119792151
dc.identifier.lattes8987735916695328
dc.identifier.lattes9514297710569236
dc.identifier.urihttp://hdl.handle.net/11449/116263
dc.identifier.wosWOS:000344168300007
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofArchives Of Dermatological Research
dc.relation.ispartofjcr2.148
dc.relation.ispartofsjr1,006
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectActinic cheilitisen
dc.subjectSquamous cell carcinomaen
dc.subjectImmunohistochemistryen
dc.subjectProto-Oncogene Proteins c-mdm2en
dc.subjectSUMO-1 proteinen
dc.titleStudy of MDM2 and SUMO-1 expression in actinic cheilitis and lip canceren
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes6967369119792151
unesp.author.lattes8987735916695328[5]
unesp.author.lattes9514297710569236
unesp.author.orcid0000-0001-7078-7708[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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