Immunohistochemical Characterization of Canine Prostatic Intraepithelial Neoplasia

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dc.contributor.authorMatsuzaki, P.
dc.contributor.authorCogliati, B.
dc.contributor.authorSanches, D. S.
dc.contributor.authorChaible, L. M.
dc.contributor.authorKimura, K. C.
dc.contributor.authorSilva, T. C.
dc.contributor.authorReal-Lima, M. A.
dc.contributor.authorHernandez-Blazquez, F. J.
dc.contributor.authorLaufer-Amorim, R. [UNESP]
dc.contributor.authorDagli, M. L. Z.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:33:19Z
dc.date.available2014-05-20T15:33:19Z
dc.date.issued2010-01-01
dc.description.abstractThe development of prostate cancer is believed to be a multistep process, progressing sequentially from normal epithelium, to prostatic intraepithelial neoplasia (PIN) and, finally, to invasive neoplasia. Malignant stem cells within the basal cell layer of the prostatic epithelium are believed to play an important role in the failure of androgen-ablation therapy that occurs in the most advanced form of prostate cancer. The aim of the present study was to immunohistochemically characterize the lesions of canine PIN. Prostatic tissue from five dogs with PIN was compared with normal prostate tissue from nine further dogs. There was an increase in the number of basal epithelial cells in lesions consistent with PIN as defined by expression of the nuclear protein p63. These lesions had elevated expression of proliferating cell nuclear antigen (PCNA) and heterogeneous labelling for the nuclear androgen receptor (AR). These findings suggest that the basal cells present in PIN may play a role in canine prostate carcinogenesis and that the proliferation of these cells occurs despite the heterogeneous expression of the AR. (C) 2009 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Pathol, Lab Expt & Comparat Oncol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Vet Med & Anim Sci, Dept Surg, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Clin Vet Med, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Clin Vet Med, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 04/14528-8
dc.description.sponsorshipIdFAPESP: 05/56291-7
dc.format.extent84-88
dc.identifierhttp://dx.doi.org/10.1016/j.jcpa.2009.06.005
dc.identifier.citationJournal of Comparative Pathology. Oxford: Elsevier B.V., v. 142, n. 1, p. 84-88, 2010.
dc.identifier.doi10.1016/j.jcpa.2009.06.005
dc.identifier.issn0021-9975
dc.identifier.urihttp://hdl.handle.net/11449/41982
dc.identifier.wosWOS:000274358800011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Comparative Pathology
dc.relation.ispartofjcr1.364
dc.relation.ispartofsjr0,594
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectandrogen receptoren
dc.subjectbasal cellen
dc.subjectdogen
dc.subjectprostatic intraepithelial neoplasiaen
dc.titleImmunohistochemical Characterization of Canine Prostatic Intraepithelial Neoplasiaen
dc.typeEditorial
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-9645-2663[4]
unesp.author.orcid0000-0001-7031-6711[10]
unesp.author.orcid0000-0002-1388-7240[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Clínica Veterinária - FMVZ