A Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observations

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dc.contributor.authorElburki, Muna S.
dc.contributor.authorRossa, Carlos [UNESP]
dc.contributor.authorGuimaraes, Morgana R. [UNESP]
dc.contributor.authorGoodenough, Mark
dc.contributor.authorLee, Hsi-Ming
dc.contributor.authorCurylofo, Fabiana A. [UNESP]
dc.contributor.authorZhang, Yu
dc.contributor.authorJohnson, Francis
dc.contributor.authorGolub, Lorne M.
dc.contributor.institutionSUNY Stony Brook
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:46Z
dc.date.available2014-12-03T13:10:46Z
dc.date.issued2014-01-01
dc.description.abstractTetracycline-based matrix metalloproteinase-(MMP-) inhibitors are currently approved for two inflammatory diseases, periodontitis and rosacea. The current study addresses the therapeutic potential of a novel pleiotropic MMP-inhibitor not based on an antibiotic. To induce experimental periodontitis, endotoxin (LPS) was repeatedly injected into the gingiva of rats on one side of the maxilla; the contralateral (control) side received saline injections. Two groups of rats were treated by daily oral intubation with a chemically modified curcumin, CMC 2.24, for two weeks; the control groups received vehicle alone. After sacrifice, gingiva, blood, and maxilla were collected, the jaws were defleshed, and periodontal (alveolar) bone loss was quantified morphometrically and by mu-CT scan. The gingivae were pooled per experimental group, extracted, and analyzed for MMPs (gelatin zymography; western blot) and for cytokines (e.g., IL-1 beta; ELISA); serum and plasma samples were analyzed for cytokines and MMP-8. The LPS-induced pathologically excessive bone loss was reduced to normal levels based on either morphometric (P = 0.003) or mu-CT (P = 0.008) analysis. A similar response was seen for MMPs and cytokines in the gingiva and blood. This initial study, on a novel triketonic zinc-binding CMC, indicates potential efficacy on inflammatory mediators and alveolar bone loss in experimental periodontitis and warrants future therapeutic and pharmacokinetic investigations.en
dc.description.affiliationSUNY Stony Brook, Sch Dent Med, Dept Oral Biol & Pathol, Stony Brook, NY 11794 USA
dc.description.affiliationUNESP, Sch Dent Araraquara, Dept Diag & Surg, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationSUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA
dc.description.affiliationUnespUNESP, Sch Dent Araraquara, Dept Diag & Surg, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipNew York State Office of Science, Technology and Academic Research (NYSTAR), through NYSTAR's Center of Advanced Technology
dc.description.sponsorshipResearch Foundation, Stony Brook University
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdNew York State Office of Science, Technology and Academic Research (NYSTAR), through NYSTAR's Center of Advanced TechnologyA43273
dc.description.sponsorshipIdResearch Foundation, Stony Brook UniversityA37298
dc.description.sponsorshipIdFAPESP: 09/54080-0
dc.description.sponsorshipIdFAPESP: 10/200912
dc.description.sponsorshipIdFAPESP: 10/19660-2
dc.description.sponsorshipIdFAPESP: 12/15826-9
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.1155/2014/959471
dc.identifier.citationMediators Of Inflammation. New York: Hindawi Publishing Corporation, 10 p., 2014.
dc.identifier.doi10.1155/2014/959471
dc.identifier.fileWOS000338870200001.pdf
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/11449/112505
dc.identifier.wosWOS:000338870200001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.relation.ispartofjcr3.549
dc.relation.ispartofsjr1,370
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleA Novel Chemically Modified Curcumin Reduces Severity of Experimental Periodontal Disease in Rats: Initial Observationsen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes7634063102292261[2]
unesp.author.orcid0000-0003-1705-5481[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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