Increasing Doxycycline Hyclate Photostability by Complexation with beta-Cyclodextrin

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dc.contributor.authorKogawa, Ana Carolina [UNESP]
dc.contributor.authorZoppi, Ariana
dc.contributor.authorAlfredo Quevedo, Mario
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.contributor.authorRaquel Longhi, Marcela
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Nacl Cordoba
dc.date.accessioned2015-03-18T15:55:53Z
dc.date.available2015-03-18T15:55:53Z
dc.date.issued2014-10-01
dc.description.abstractDoxycycline hyclate (DOX) is a highly photosensitive drug, a feature that limits the stability of the corresponding dosage forms. The main objectives of this work were the preparation and characterization of an inclusion complex of DOX with beta-cyclodextrin (beta CD) and to investigate if this approach could improve the photostability of the drug. Guest-host interactions were investigated using nuclear magnetic resonance, which were afterwards combined with molecular modeling methods to study the complex formation and its three-dimensional structure was proposed. A freeze-drying method was applied to obtain the complex in the solid state, which was further confirmed by thermal and spectroscopic techniques. To evaluate the complexation effect on DOX integrity, the photostability of the inclusion complex was studied, with a significant decrease in the photodegradation of DOX being found in aqueous solution upon complexation. Finally, the photoprotection produced by the complexation was evaluated by means of an antimicrobial assay. Overall, the presented results suggest that the formulation of DOX complexed with beta CD constitutes an interesting approach for the preparation of pharmaceutical dosage forms of DOX with enhanced stability properties.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Sao Paulo, Brazil
dc.description.affiliationUniv Nacl Cordoba, Unidad Invest & Desarrollo Tecnol Farmaceut UNITE, CONICET, RA-5000 Cordoba, Argentina
dc.description.affiliationUniv Nacl Cordoba, Dept Farm, Fac Ciencias Quim, RA-5000 Cordoba, Argentina
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Sao Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipPADC-FCF
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipSecretaria de Ciencia y Tecnica de la Universidad Nacional de Cordoba (SECyT)
dc.description.sponsorshipConsejo Nacional de Investigaciones Cientificas y Tecnologicas de la Nacion Argentina (CONICET)
dc.format.extent1209-1217
dc.identifierhttp://dx.doi.org/10.1208/s12249-014-0150-7
dc.identifier.citationAaps Pharmscitech. New York: Springer, v. 15, n. 5, p. 1209-1217, 2014.
dc.identifier.doi10.1208/s12249-014-0150-7
dc.identifier.issn1530-9932
dc.identifier.urihttp://hdl.handle.net/11449/117342
dc.identifier.wosWOS:000342489200018
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofAaps Pharmscitech
dc.relation.ispartofjcr2.666
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbeta-cyclodextrinen
dc.subjectdoxycycline hyclateen
dc.subjectmicrobiological assayen
dc.subjectmolecular modelingen
dc.subjectphotostabilityen
dc.titleIncreasing Doxycycline Hyclate Photostability by Complexation with beta-Cyclodextrinen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.orcid0000-0002-0385-340X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR