Androgen therapy reverses injuries caused by ethanol consumption in the prostate: testosterone as a possible target to ethanol-related disorders

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dc.contributor.authorMendes, Leonardo O.
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.authorRochel-Maia, Sabrina S.
dc.contributor.authorFioruci-Fontaneli, Beatriz A.
dc.contributor.authorChuffa, Luiz G. A. [UNESP]
dc.contributor.authorAnselmo-Franci, Janete A.
dc.contributor.authorMartinez, Francisco E. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Biosci Humanities &Exact Sci
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-10-21T13:11:48Z
dc.date.available2015-10-21T13:11:48Z
dc.date.issued2015-01-01
dc.description.abstractAims: Chronic ethanol consumption leads to reproductive damages, since it can act directly in the tissues or indirectly, causing a hormonal imbalance. Prostate is a hormone-dependent gland and, consequently, susceptible to ethanol. The potential of testosterone therapy in the ethanol-related disorders was investigated in the prostate microenvironmentMain methods: UChB rats aged 90 days were divided into 2 experimental groups (n = 20): C: drinking water only and EtOH: drinking 10% (v/v) ethanol at >2 g/kg body weight! day + water. At 150 days old, 10 rats from each group received subcutaneous injections of testosterone cypionate (5 mg/kg body weight) diluted in corn oil every other day for 4 weeks, constituting T and EtOH+T, while the remaining animals received corn oil as vehicle. Animals were euthanized at 180 days old, by decapitation. Blood was collected to obtain hormone concentrations and ventral prostate was dissected and processed for light microscope and molecular analyses.Key findings: Ventral prostate weight, plasma testosterone and DHT and intraprostatic testosterone concentrations were increased after testosterone treatment Plasma estradiol level was reduced in the EtOH +T. Inflammatory foci, metaplasia and epithelial atrophy were constantly found in the prostate of EtOH and were not observed after hormonal therapy. No differences were found in the expression of AR, ER beta and DACH-1. Additionally, testosterone treatment down-regulated ER alpha and increased the e-cadherin and a-actinin immunoreactivities.Significance: Testosterone was able to reverse damages caused by ethanol consumption in the prostate microenvironment and becomes a possible target to be investigated to ethanol-related disorders. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationState Univ Campinas UNICAMP, Struct &Cell Biol Program, Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biosci, Dept Morphol, BR-18618910 Botucatu, SP, Brazil
dc.description.affiliationInst Biosci Humanities &Exact Sci, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biosci, Dept Anat, BR-18618910 Botucatu, SP, Brazil
dc.description.affiliationUniv Sao Paulo, USP, Dept Morphol Stomatol &Physiol, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biosci, Dept Morphol, BR-18618910 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biosci, Dept Anat, BR-18618910 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2009/54606-1
dc.description.sponsorshipIdFAPESP: 2011/05936-9
dc.description.sponsorshipIdFAPESP: 2012/00917-9
dc.format.extent22-30
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0024320514009047
dc.identifier.citationLife Sciences, v. 120, p. 22-30, 2015.
dc.identifier.doi10.1016/j.lfs.2014.11.003
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/11449/128642
dc.identifier.wosWOS:000348693700004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLife Sciences
dc.relation.ispartofjcr3.234
dc.relation.ispartofsjr1,071
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectEthanolen
dc.subjectProstateen
dc.subjectTestosterone therapyen
dc.subjectHormonal receptorsen
dc.titleAndrogen therapy reverses injuries caused by ethanol consumption in the prostate: testosterone as a possible target to ethanol-related disordersen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-6682-2934[2]
unesp.author.orcid0000-0002-6480-1187[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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