Long-term toxicity following acute administration of nickel

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dc.contributor.authorNovelli, E. L B [UNESP]
dc.contributor.authorNovelli Filho, J. L V B [UNESP]
dc.contributor.authorRodrigues, N. L. [UNESP]
dc.contributor.authorRibas, B. O.
dc.contributor.authorBarbosa, L. L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMinisterio de Sanidad y Consumo
dc.contributor.institutionDelegacia de Ensino de Botucatu
dc.date.accessioned2014-05-27T11:19:35Z
dc.date.available2014-05-27T11:19:35Z
dc.date.issued1998-07-14
dc.description.abstractNickel compounds have high potential risk for the health of populations and for this reason their toxic effects should be urgently established. To determine the effect of nickel monosulfide in the muscle at the injection site on pancreatic, hepatic, and osteogenic lesions and the potential therapeutic effect of Cu-Zn superoxide dismutase (SOD), male Wistar rats received single intramuscular injections of nickel monosulfide (NiS - 7 mg Ni2+/Kg). A group of these experimental rats were injected intraperitoneally, with a single weekly dose of SOD covalently linked to polyethylene glycol (SOD-PEG). Rats were sacrificed at 2, 4, 6, and 8 months after Ni2+ injection. Nickel monosulfide produced tumors at the injection site. The increased phospholipid, alanine transaminase (ALT), alkaline phosphatase (ALP), and amylase levels in serum, in absence of SOD-PEG, reflected the toxic effects on pancreatic, hepatic, and osteogenic tissues of rats. SOD activity was increased in serum of rats receiving SOD-PEG throughout the experiment, and no significant difference was observed in biochemical parameters of control and experimental rats in presence of SOD- PEG. Superoxide radical generated by Ni2+ is of primary importance in the development of tumors at the injection site. Superoxide anion (O2 -) is also an important toxic intermediate with respect to hepatic, pancreatic, and osteogenic injury, since SOD-PEG has a potential therapeutic effect.en
dc.description.affiliationDepartment of Chemistry Instituto de Biociencias Universidade Estadual Paulista, Botucatu, São Paulo
dc.description.affiliationFaculty of Medicine Universidade Estadual Paulista, Botucatu, São Paulo
dc.description.affiliationDepartment of Toxicology Natl. Centre of Environmental Health Ministerio de Sanidad y Consumo, Madrid
dc.description.affiliationDelegacia de Ensino de Botucatu, São Paulo
dc.description.affiliationDepartamento de Quimica Instituto de Biociências Univ. Estadual Paulista - UNESP, 18618000, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Chemistry Instituto de Biociencias Universidade Estadual Paulista, Botucatu, São Paulo
dc.description.affiliationUnespFaculty of Medicine Universidade Estadual Paulista, Botucatu, São Paulo
dc.description.affiliationUnespDepartamento de Quimica Instituto de Biociências Univ. Estadual Paulista - UNESP, 18618000, Botucatu, São Paulo
dc.format.extent175-185
dc.identifierhttp://www.ingentaconnect.com/content/tandf/utsm/1998/00000017/00000003/art00002
dc.identifier.citationToxic Substance Mechanisms, v. 17, n. 3, p. 175-185, 1998.
dc.identifier.issn1076-9188
dc.identifier.scopus2-s2.0-13144283657
dc.identifier.urihttp://hdl.handle.net/11449/65475
dc.identifier.wosWOS:000074537900002
dc.language.isoeng
dc.relation.ispartofToxic Substance Mechanisms
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectIntramuscular
dc.subjectNickel monosulfide
dc.subjectRats
dc.subjectSuperoxide radical
dc.subjectTumor
dc.subjectalanine aminotransferase
dc.subjectalkaline phosphatase
dc.subjectamylase
dc.subjectcopper zinc superoxide dismutase
dc.subjectglutathione peroxidase
dc.subjectmacrogol
dc.subjectmalonaldehyde
dc.subjectnickel subsulfide
dc.subjectphospholipid
dc.subjectsuperoxide
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbone injury
dc.subjectcarcinogenesis
dc.subjectchelation therapy
dc.subjectchronic toxicity
dc.subjectcontrolled study
dc.subjectcovalent bond
dc.subjectenzyme activity
dc.subjecthealth hazard
dc.subjectinjection site
dc.subjectintramuscular drug administration
dc.subjectintraperitoneal drug administration
dc.subjectliver injury
dc.subjectmale
dc.subjectmuscle tumor
dc.subjectnonhuman
dc.subjectpancreas injury
dc.subjectrat
dc.subjectAnimalia
dc.subjectRattus norvegicus
dc.titleLong-term toxicity following acute administration of nickelen
dc.typeArtigo
dcterms.licensehttp://www.ingentaconnect.com/about/terms
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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