Central nifedipine-induced alterations in salivary flow and compounds: Role of nitric oxide

Página do item simplificado
dc.contributor.authorSaad, Wilson Abrão [UNESP]
dc.contributor.authorGuarda, Ismael Francisco Motta Siqueira
dc.contributor.authorCamargo, Luiz Antonio de Arruda [UNESP]
dc.contributor.authorSantos, Talmir Augusto Faria Brizola dos
dc.contributor.authorSimões, Sylvio
dc.contributor.authorSaad, William Abrão
dc.contributor.institutionUniversidade de Taubaté (UNITAU)
dc.contributor.institutionCentro Universitário de Araraquara (UNIARA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-27T11:21:52Z
dc.date.available2014-05-27T11:21:52Z
dc.date.issued2006-05-01
dc.description.abstractThe aim of this study was to examine the role of nifedipine and Nitric Oxide (NO) on salivary flow and compounds (salivary amylase, saliva total proteins, saliva calcium, sodium and potassium). Male Holtzman rats weighting 200-250 g were anesthetized with zoletil 50 mg kg -1 (tiletamine chloridrate 125.0 mg and zolazepan chloridrate 125.0 mg) into quadriceps muscle and stainless steel cannulas were implanted into their lateral ventricle of the brain (LV). Animals in divided group were injected with nifedipine (50 μg μL -1) alone and in combination with 7-nitroindazol (7-NIT) (40 μg μL -1), neuronal NO Sinthase Inhibitor (nNOSI) and Sodium Nitroprussate (SNP) (30 μg μL -1) NO donor agent. As a secretory stimuli, pilocarpine dissolved in isotonic was administered intraperitoneally (ip) at a dosage of 10 mg kg -1 body weight. Saliva was collected for 7 min with four cotton balls weighing approximately 20 mg each, two of which were placed on either side of the oral cavity, with the other two placed under the tongue. Nifedipine treatment induced a reduction in saliva secretion rate and concentration of amylase, total protein and calcium without changes in sodium and potassium concentration in comparison with controls. Co-treatment of animals with nifedipine and SNP retained flow rate and concentration of amylase, total protein and calcium in normal levels. Co-treatment of animals with nifedipine and 7-NIT potentiated the effect of nifedipine on the reduction of saliva secretion and concentrations of amylase, total protein and calcium. Nifedipine (dihydroperidine) calcium-channel blocker widely in use is associated with salivary dysfunction acting in the central nervous system structures. NO might be the mechanism for protective effect against the nifedipine-induce salivary dysfunction, acting in the CNS. © 2006 Asian Network for Scientific Information.en
dc.description.affiliationBasic Institute of Biosciences UNITAU, Taubaté, SP
dc.description.affiliationDepartment of Biological and Health Science UNIARA, Araraquara, SP
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry Paulista State University, 1680 Humaitá Street, Araraquara, SP 14801-903
dc.description.affiliationDepartment of Anesthesiology Clinic Hospital State of São Paulo, São Paulo
dc.description.affiliationDepartment of Physiology Federal University of São Carlos SP, São Paulo
dc.description.affiliationDepartment of Gastroenterology Clinic Hospital State of São Paulo, São Paulo
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry Paulista State University, 1680 Humaitá Street, Araraquara, SP 14801-903
dc.format.extent596-603
dc.identifierhttp://dx.doi.org/10.3923/jbs.2006.596.603
dc.identifier.citationJournal of Biological Sciences, v. 6, n. 3, p. 596-603, 2006.
dc.identifier.doi10.3923/jbs.2006.596.603
dc.identifier.issn1727-3048
dc.identifier.issn1812-5719
dc.identifier.scopus2-s2.0-33745769561
dc.identifier.urihttp://hdl.handle.net/11449/68875
dc.language.isoeng
dc.relation.ispartofJournal of Biological Sciences
dc.relation.ispartofsjr0,174
dc.relation.ispartofsjr0,174
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectLateral ventricle
dc.subjectNifedipine
dc.subjectNitric oxide
dc.subjectSaliva
dc.subjectWater intake
dc.subject7 nitroindazole
dc.subjectamylase
dc.subjectcalcium
dc.subjectisotonic solution
dc.subjectnifedipine
dc.subjectnitric oxide
dc.subjectnitric oxide donor
dc.subjectnitric oxide synthase inhibitor
dc.subjectnitroprusside sodium
dc.subjectpilocarpine
dc.subjectpotassium
dc.subjectsaliva protein
dc.subjectsodium
dc.subjectstainless steel
dc.subjecttelazol
dc.subjectanalysis of variance
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarterial pressure
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectdrug potentiation
dc.subjectflow rate
dc.subjectfluid intake
dc.subjecthistopathology
dc.subjectlateral brain ventricle
dc.subjectmale
dc.subjectnonhuman
dc.subjectquadriceps femoris muscle
dc.subjectrat
dc.subjectsalivation disorder
dc.subjectAnimalia
dc.subjectGossypium hirsutum
dc.titleCentral nifedipine-induced alterations in salivary flow and compounds: Role of nitric oxideen
dc.typeArtigo
dcterms.licensehttp://scialert.net/licence_to_publish.pdf
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Coleções

Artigos - Fisiologia e Patologia - FOAR