Proteomic analysis of dog tears for potential cancer markers

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dc.contributor.authorCampos, Carla de Freitas [UNESP]
dc.contributor.authorCole, Nerida
dc.contributor.authorVan Dyk, Derek
dc.contributor.authorWalsh, Bradley J.
dc.contributor.authorDiakos, Penelope
dc.contributor.authorAlmeida, Denise [UNESP]
dc.contributor.authorTorrecilhas, Adriana [UNESP]
dc.contributor.authorLaus, Jose Luiz [UNESP]
dc.contributor.authorWillcox, Mark D. P.
dc.contributor.institutionUniv New S Wales
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionVis Cooperat Res Ctr
dc.contributor.institutionMinom Pty Ltd
dc.date.accessioned2014-05-20T13:14:17Z
dc.date.available2014-05-20T13:14:17Z
dc.date.issued2008-10-01
dc.description.abstractThe first reference map of the proteome of pooled normal dog tears was created using 2-dimensional polyacrylamide gel electrophoresis and the identity of a number of the major species determined using matrix-assisted laser desorption time of flight mass spectrometry (MALDI-TOF) and peptide mass fingerprint matching on protein sequence databases. In order to understand the changes in protein expression in the tear film of dogs with cancer, tears from such animals were similarly examined. A number of differences were found between the tears of healthy dogs and the dogs with cancer. Differences were found in levels of actin and albumin and in an unidentified protein which may be analogous to human lacryglobulin. These findings suggest that it may be possible to develop tear film analysis to provide a simple non-invasive test for the diagnosis and/or management of canine cancers. (C) 2007 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv New S Wales, Eye Res Inst, Kensington, NSW 2052, Australia
dc.description.affiliationSão Paulo State Univ, Vet Ophthalmol Unit, São Paulo, Brazil
dc.description.affiliationVis Cooperat Res Ctr, Sydney, NSW, Australia
dc.description.affiliationMinom Pty Ltd, Chatswood W, NSW, Australia
dc.description.affiliationUniv New S Wales, Sch Optometry & Vis Sci, Sydney, NSW 2052, Australia
dc.description.affiliationUnespSão Paulo State Univ, Vet Ophthalmol Unit, São Paulo, Brazil
dc.format.extent349-352
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2007.11.006
dc.identifier.citationResearch In Veterinary Science. Oxford: Elsevier B.V., v. 85, n. 2, p. 349-352, 2008.
dc.identifier.doi10.1016/j.rvsc.2007.11.006
dc.identifier.issn0034-5288
dc.identifier.urihttp://hdl.handle.net/11449/1803
dc.identifier.wosWOS:000258188300023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofjcr1.616
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subject2-dimensional electrophoresisen
dc.subjectDogen
dc.subjecttearsen
dc.subjectneoplasmen
dc.titleProteomic analysis of dog tears for potential cancer markersen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-9866-4694[2]
unesp.author.orcid0000-0003-3571-4399[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Clínica e Cirurgia Veterinária - FCAV