Peripheral giant cell granuloma. An immunohistochemical and ultrastructural study.

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dc.contributor.authorCarvalho, Y. R.
dc.contributor.authorLoyola, A. M.
dc.contributor.authorGomez, R. S.
dc.contributor.authorAraújo, V. C.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:18:00Z
dc.date.available2014-05-27T11:18:00Z
dc.date.issued1995-03-01
dc.description.abstractOBJECTIVE: To study the nature of multinucleated and mononuclear cells from peripheral giant cell granuloma (PGCG). MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded sections of 40 cases of PGCG were immunohistochemically stained for vimentin, alpha I-antichymotrypsin, CD68, S-100 protein, lysozyme, leucocyte common antigen (LCA), factor VIII-related antigen and muscle cell actin. Six cases of PGCG were also studied by transmission electron microscopy. RESULTS: Vimentin, alpha I-antichymotrypsin and CD68 were expressed in both the mononuclear and multinucleated giant cells. Dendritic mononuclear cells, positive for S-100 protein, were noted in 67.5% of the lesions, whereas lysozyme and leucocyte common antigen were detected in occasional mononuclear cells. Ultrastructural examination showed mononuclear cells with signs of phagocytosis and sometimes interdigitations with similar cells. Others presented non-specific characteristics and the third type exhibited cytoplasmic processes and occasional Birbeck granules. Some multinucleated giant cells showed oval nuclei, abundant mitochondria and granular endoplasmic reticulum whereas others presented with irregular nuclei and a great number of cytoplasmic vacuoles. CONCLUSIONS: Immunohistochemical and ultrastructural results suggest that PGCGs of the jaws are composed mainly of cells of the mononuclear phagocyte system and that Langerhans cells are present in two thirds of the lesions.en
dc.format.extent20-25
dc.identifierhttp://dx.doi.org/10.1111/j.1601-0825.1995.tb00152.x
dc.identifier.citationOral diseases, v. 1, n. 1, p. 20-25, 1995.
dc.identifier.doi10.1111/j.1601-0825.1995.tb00152.x
dc.identifier.issn1354-523X
dc.identifier.scopus2-s2.0-0029265031
dc.identifier.urihttp://hdl.handle.net/11449/64597
dc.language.isoeng
dc.relation.ispartofOral Diseases
dc.relation.ispartofjcr2.310
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectactin
dc.subjectalpha 1 antichymotrypsin
dc.subjectCD45 antigen
dc.subjectCD68 antigen, human
dc.subjectdifferentiation antigen
dc.subjectleukocyte antigen
dc.subjectlysozyme
dc.subjectmonoclonal antibody
dc.subjectprotein S 100
dc.subjectvimentin
dc.subjectvon Willebrand factor
dc.subjectchemistry
dc.subjectelectron microscopy
dc.subjectenzyme immunoassay
dc.subjectgiant cell
dc.subjectgiant cell granuloma
dc.subjectgingiva disease
dc.subjecthuman
dc.subjectLangerhans cell
dc.subjectpathology
dc.subjectphagocyte
dc.subjectretrospective study
dc.subjectultrastructure
dc.subjectActins
dc.subjectalpha 1-Antichymotrypsin
dc.subjectAntibodies, Monoclonal
dc.subjectAntigens, CD
dc.subjectAntigens, CD45
dc.subjectAntigens, Differentiation, Myelomonocytic
dc.subjectGiant Cells
dc.subjectGingival Diseases
dc.subjectGranuloma, Giant Cell
dc.subjectHuman
dc.subjectImmunoenzyme Techniques
dc.subjectLangerhans Cells
dc.subjectMicroscopy, Electron
dc.subjectMuramidase
dc.subjectPhagocytes
dc.subjectRetrospective Studies
dc.subjectS100 Proteins
dc.subjectVimentin
dc.subjectvon Willebrand Factor
dc.titlePeripheral giant cell granuloma. An immunohistochemical and ultrastructural study.en
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html

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