Effects of lisinopril on experimental ischemia in rats. Influence of infarct size

Página do item simplificado
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorTornero, Maria T. T. [UNESP]
dc.contributor.authorSpadaro, Joel [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:18:27Z
dc.date.available2014-05-20T15:18:27Z
dc.date.issued1999-10-01
dc.description.abstractOBJECTIVE - Angiotensin-converting enzyme inhibitors (ACEIs) have gained importance in preventing or attenuating the process of ventricular remodeling after myocardial infarction. The significance of infarct size in regard to the response to ACEIs, however, is controversial. This study aimed to analyze the effects of lisinopril on mortality rate, cardiac function, degree of cardiac hypertrophy and fibrosis in rats with different infarct sizes. METHODS - Lisinopril (20 mg/kg/day) dissolved in drinking water was administered to rats immediately after coronary artery occlusion. After being sacrificed, the infarcted animals were divided into two groups: one group of animals with small infarcts (< 40% of the left ventricle) and another group of animals with large infarcts (> 40% of the left ventricle). RESULTS - The mortality rate was 31.7% in treated rats and 47% in the untreated rats. There was no statistical difference between the groups with small and large infarcts in regard to myocardial concentration of hydroxyproline. In small infarcts, the treatment attenuated the heart dysfunction characterized by lower levels of blood pressure and lower values of the first derivative of pressure and of the negative derivative of pressure. The degree of hypertrophy was also attenuated in small infarcts. In regard to large infarcts, no differences between the groups were observed. CONCLUSION - Treatment with the ACEIs had no effect on mortality rate and on the amount of fibrosis. The protective effect of lisinopril on heart function and on the degree of hypertrophy could only be detected in small infarctsen
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Medicina de Botucatu
dc.format.extent366-372
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X1999001000004
dc.identifier.citationArquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 73, n. 4, p. 366-372, 1999.
dc.identifier.doi10.1590/S0066-782X1999001000004
dc.identifier.fileS0066-782X1999001000004.pdf
dc.identifier.issn0066-782X
dc.identifier.lattes6990977122340795
dc.identifier.lattes6309835137998766
dc.identifier.lattes5016839015394547
dc.identifier.scieloS0066-782X1999001000004
dc.identifier.urihttp://hdl.handle.net/11449/30898
dc.language.isoeng
dc.publisherSociedade Brasileira de Cardiologia (SBC)
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectmyocardial infarctionen
dc.subjectraten
dc.subjectlisinoprilen
dc.titleEffects of lisinopril on experimental ischemia in rats. Influence of infarct sizeen
dc.typeArtigo
unesp.author.lattes5016839015394547
unesp.author.lattes6990977122340795
unesp.author.lattes6309835137998766
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S0066-782X1999001000004.pdf
Tamanho:
61.82 KB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Clínica Médica - FMB