T and B lymphocytes in the brains of dogs with concomitant seropositivity to three pathogenic protozoans: Leishmania chagasi, Toxoplasma gondii and Neospora caninum

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dc.contributor.authorSakamoto, Keila Priscilla [UNESP]
dc.contributor.authorDe Melo, Guilherme Dias [UNESP]
dc.contributor.authorMachado, Gisele Fabrino [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:40Z
dc.date.available2014-05-27T11:29:40Z
dc.date.issued2013-06-11
dc.description.abstractBackground: Visceral leishmaniasis is a disease with great variability regarding the clinical manifestations in humans and dogs. Chronically infected dogs may develop neurological disorders, however, there are few reports that characterize the lesions and make clear the pathogenesis of the canine cerebral leishmaniasis. Concomitant with Leishmania chagasi, dogs may be infected by opportunistic pathogens, such as Toxoplasma gondii and Neospora caninum, which may contribute to the occurrence of lesions in the central nervous system. Hence, we aimed to compare the T and B lymphocytes population in the brains of infected dogs with seropositivity to L. chagasi, T. gondii and N. caninum concurrently (n = 24), seropositivity only to L. chagasi (n = 31), and seropositivity to T. gondii and N. caninum (n = 16). Uninfected dogs were used as control (n = 10). Results: Inflammatory lesions, characterised by mononuclear cell accumulation, composed mainly of CD3+ T lymphocytes predominated in several encephalic regions of the dogs from all the three infected groups, with no difference among them (P = 0.0004), whereas CD79α+ B lymphocytes were detected in very small intensity and presented no difference among groups (P = 0.5313). Furthermore, no association among diseases was detected at the serological enquire. Conclusions: We demonstrate that the peripheral infection by L. chagasi per se can promote the influx of lymphocytes within the nervous milieu as occurs during Toxoplasma and Neospora infections, and the concomitant seropositivity against these pathogens does not exacerbate the inflammatory brain lesions. Therefore, these findings give additional support that the brain should be included in the list of organs affected by visceral leishmaniasis and that even asymptomatic infected dogs may develop brain lesions. © 2013 Sakamoto et al.; licensee BioMed Central Ltd.en
dc.description.affiliationLaboratory of Applied Pathology (LAPAP) College of Veterinary Medicine Universidade Estadual Paulista (UNESP), Rua Clóvis Pestana 739, CEP 16050-680, Araçatuba, São Paulo
dc.description.affiliationUnespLaboratory of Applied Pathology (LAPAP) College of Veterinary Medicine Universidade Estadual Paulista (UNESP), Rua Clóvis Pestana 739, CEP 16050-680, Araçatuba, São Paulo
dc.identifierhttp://dx.doi.org/10.1186/1756-0500-6-226
dc.identifier.citationBMC Research Notes, v. 6, n. 1, 2013.
dc.identifier.doi10.1186/1756-0500-6-226
dc.identifier.file2-s2.0-84878646777.pdf
dc.identifier.issn1756-0500
dc.identifier.scopus2-s2.0-84878646777
dc.identifier.urihttp://hdl.handle.net/11449/75634
dc.language.isoeng
dc.relation.ispartofBMC Research Notes
dc.relation.ispartofsjr0,691
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCD3
dc.subjectCD79α
dc.subjectCentral Nervous System
dc.subjectInflammation
dc.subjectLymphocyte
dc.subjectNeosporosis
dc.subjectToxoplasmosis
dc.subjectVisceral Leishmaniasis
dc.subjectCanis familiaris
dc.subjectLeishmania donovani chagasi
dc.subjectNeospora
dc.subjectNeospora caninum
dc.subjectProtozoa
dc.subjectToxoplasma
dc.subjectToxoplasma gondii
dc.titleT and B lymphocytes in the brains of dogs with concomitant seropositivity to three pathogenic protozoans: Leishmania chagasi, Toxoplasma gondii and Neospora caninumen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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