Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw

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dc.contributor.authorHadad, Henrique [UNESP]
dc.contributor.authorKawamata de Jesus, Laís [UNESP]
dc.contributor.authorPiquera Santos, Ana Flávia [UNESP]
dc.contributor.authorRinaldi Matheus, Henrique [UNESP]
dc.contributor.authorde Souza Rodrigues, Letícia Gabriella [UNESP]
dc.contributor.authorPaolo Poli, Pier
dc.contributor.authorMarcantonio Junior, Elcio [UNESP]
dc.contributor.authorPozzi Semeghini Guastaldi, Fernando
dc.contributor.authorMaiorana, Carlo
dc.contributor.authorMilanezi de Almeida, Juliano [UNESP]
dc.contributor.authorOkamoto, Roberta [UNESP]
dc.contributor.authorÁvila Souza, Francisley [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Milan
dc.contributor.institutionHarvard School of Dental Medicine
dc.date.accessioned2023-07-29T14:32:18Z
dc.date.available2023-07-29T14:32:18Z
dc.date.issued2022-12-01
dc.description.abstractSurgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, β-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% ± 2.65), and the highest in aDBG (69.85% ± 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 ± 0.48) and DBG (2.30 ± 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% ± 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 ± 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction.en
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, São Paulo
dc.description.affiliationDepartment of Biomedical Surgical and Dental Sciences Implant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico University of Milan
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationSkeletal Biology Research Center Department of Oral and Maxillofacial Surgery Massachusetts General Hospital (MGH) Harvard School of Dental Medicine
dc.description.affiliationDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, São Paulo
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2019/22657-8
dc.description.sponsorshipIdFAPESP: 2019/27609-1
dc.description.sponsorshipIdCAPES: 88887.570145/2020-00
dc.identifierhttp://dx.doi.org/10.1038/s41598-022-20128-4
dc.identifier.citationScientific Reports, v. 12, n. 1, 2022.
dc.identifier.doi10.1038/s41598-022-20128-4
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85139163088
dc.identifier.urihttp://hdl.handle.net/11449/249224
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.sourceScopus
dc.titleBeta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jawen
dc.typeArtigo

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Artigos - Diagnóstico e Cirurgia - FOAR
Artigos - Ciências Básicas - FOA