EFFECTS OF CYCLOSPORINE-A IMMUNOSUPPRESSION ON PANCREATICODUODENAL TRANSPLANTATION IN ALLOXAN-DIABETIC RATS

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dc.contributor.authorSpadella, César Tadeu [UNESP]
dc.contributor.authorBreim, L. C.
dc.contributor.authorMercadante, MCS
dc.contributor.authorMachado, JLM
dc.contributor.authorDemacedo, A. R.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:19:42Z
dc.date.available2014-05-20T15:19:42Z
dc.date.issued1992-01-01
dc.description.abstract1. Forty-five outbred Wistar rats were randomly assigned to three experimental groups: GI, 10 non-diabetic control rats; GII, 10 alloxan-diabetic control rats; GIII, 25 alloxan-diabetic tats which received pancreaticoduodenal transplantation (PDT) from normal Wistar donor rats and were immunosuppressed with cyclosporin A (Cy-A), 10 mg kg body weight-1 day-1, administered intraperitoneally for 30 days.2. In parallel, 15 alloxan-diabetic inbred Wistar rats received isogeneic PDT from normal Wistar donor rats.3. Cy-A prevented graft rejection in the 15 surviving animals in group III. These observations were confirmed by clinical and biochemical parameters (body weight, urine output, water and food intake, blood and urinary glucose and plasma insulin) and by histology and immunohistochemistry of the pancreas.4. However, Cy-A was associated with 60% of the infectious complications in transplanted rats leading to 40% mortality. Pulmonary infections were the main cause of death. There were no side effects of immunosuppression on the pancreas. Infections were not significant in inbred rats submitted to PDT.en
dc.description.affiliationUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FAC MED BOTUCATU,DEPT CIRURGIA & ORTOPEDIA,BR-18618-000 BOTUCATU,SP,BRAZIL
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FAC MED BOTUCATU,DEPT CIRURGIA & ORTOPEDIA,BR-18618-000 BOTUCATU,SP,BRAZIL
dc.format.extent1185-1195
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 25, n. 12, p. 1185-1195, 1992.
dc.identifier.issn0100-879X
dc.identifier.lattes6223012281302736
dc.identifier.urihttp://hdl.handle.net/11449/31107
dc.identifier.wosWOS:A1992KG52600004
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPANCREAS TRANSPLANTATIONpt
dc.subjectEXPERIMENTAL DIABETESpt
dc.subjectALLOXAN-INDUCED DIABETESpt
dc.subjectCYCLOSPORINEpt
dc.titleEFFECTS OF CYCLOSPORINE-A IMMUNOSUPPRESSION ON PANCREATICODUODENAL TRANSPLANTATION IN ALLOXAN-DIABETIC RATSen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjmbr/iaboutj.htm
dcterms.rightsHolderAssociação Bras Divulg Cientifica
unesp.author.lattes6223012281302736
unesp.author.orcid0000-0001-5514-6611[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Cirurgia e Ortopedia - FMB