Effects of Compounds from Passiflora edulis Sims f. flavicarpa Juice on Blood Coagulation and on Proteolytic Enzymes

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dc.contributor.authorSato, Ana Claudia
dc.contributor.authorAndrade, Sonia A.
dc.contributor.authorBrito, Marlon V.
dc.contributor.authorMiranda, Antonio
dc.contributor.authorSampaio, Misako Uemura
dc.contributor.authorMaffei, Francisco Humberto de Abreu [UNESP]
dc.contributor.authorVilela Oliva, Maria Luiza
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHosp Santa Catarina
dc.date.accessioned2014-05-20T13:32:39Z
dc.date.available2014-05-20T13:32:39Z
dc.date.issued2012-05-01
dc.description.abstractPassion fruit (Passiflora edulis Sims f. flavicarpa) is popularly known for its sedative and calming properties and is consumed as a fresh fruit or as a juice. The clinical observation of blood incoagulability associated with excessive consumption of passion fruit juice, in a patient treated with warfarin, prompted the current study to investigate in vitro the presence of blood clotting inhibitors in Passiflora edulis Sims f. flavicarpa extract. After purification process, two compounds of distinct molecular weight and inhibitory action were better characterized. One is a trypsin inhibitor similar to inhibitors from Bowman-Birk family, named PeTI-I12, and other is a compound active in coagulation that prolongs aPTT and PT, but does not change TT. The aim of this study is to provide evidence that passion fruit extract's components play a role on hemostasis and therefore may be relevant in the handling of patients treated with anticoagulants or suffering hemorrhagic diseases.en
dc.description.affiliationUniv Fed São Paulo, Escola Paulista Med, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, Escola Paulista Med, Dept Biofis, BR-04044020 São Paulo, Brazil
dc.description.affiliationInst Butantan, Lab Bioquim & Biofis, São Paulo, Brazil
dc.description.affiliationUniv Estadual São Paulo, UNESP, Escola Med Botucatu, Dept Cirurgia & Ortopedia, Botucatu, SP, Brazil
dc.description.affiliationHosp Santa Catarina, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual São Paulo, UNESP, Escola Med Botucatu, Dept Cirurgia & Ortopedia, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent501-508
dc.identifierhttp://eurekaselect.com/96614/article
dc.identifier.citationProtein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 19, n. 5, p. 501-508, 2012.
dc.identifier.issn0929-8665
dc.identifier.urihttp://hdl.handle.net/11449/11141
dc.identifier.wosWOS:000303311100004
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofProtein and Peptide Letters
dc.relation.ispartofjcr1.039
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectaPTTen
dc.subjectblood coagulationen
dc.subjectBowman-Birk inhibitoren
dc.subjectPassiflora edulisen
dc.subjectpassion fruiten
dc.subjectPassifloraceaeen
dc.subjecttrypsin inhibitoren
dc.subjectwarfarinen
dc.titleEffects of Compounds from Passiflora edulis Sims f. flavicarpa Juice on Blood Coagulation and on Proteolytic Enzymesen
dc.typeArtigo
dcterms.licensehttp://www.benthamscience.com/permission.php
dcterms.rightsHolderBentham Science Publ Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Cirurgia e Ortopedia - FMB