Changes in taste reactivity to intra-oral hypertonic NaCl after lateral parabrachial injections of an alpha(2)-adrenergic receptor agonist

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dc.contributor.authorAndrade, Carina A. F. [UNESP]
dc.contributor.authorAndrade-Franze, Glaucia M. F. [UNESP]
dc.contributor.authorDe Luca, Laurival A. [UNESP]
dc.contributor.authorJohnson, Alan Kim
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Iowa
dc.date.accessioned2014-05-20T13:46:15Z
dc.date.available2014-05-20T13:46:15Z
dc.date.issued2011-10-24
dc.description.abstractBilateral injections of moxonidine, an alpha(2)-adrenoceptor and imidazoline receptor agonist, into the lateral parabrachial nuclei (LPBN) enhance sodium appetite induced by extracellular dehydration. In the present study, we examined whether LPBN moxonidine treatments change taste reactivity to hypertonic NaCl solution administered into the mouth by intra-oral (IO) cannula. Male Holtzman rats prepared with IO and bilateral LPBN cannulas received subcutaneous injections of furosemide (FURO; 10 mg/kg) and captopril (CAP; 5 mg/kg) to induce hypovolemia with mild hypotension and an accompanying salt appetite and thirst before testing the taste reactivity to oral infusions of 0.3 M NaCl (1.0 ml/min). In the first experiment 45 min after subcutaneous injections of FURO + CAP or vehicle, moxonidine was bilaterally injected into the LPBN, and then 15 min later both bodily and oral-facial ingestive and rejection responses to 0.3 M NaCl delivered through the IO cannula were assessed. Both LPBN vehicle and moxonidine treated rats showed increased ingestive and decreased rejection responses to the IO hypertonic solution. The 100.3 M NaCl infusion-evoked ingestive and rejection taste related behaviors were comparable in the LPBN vehicle- vs. the LPBN moxonidine-injected groups. In a second experiment, rats received the same FURO + CAP treatments and LPBN injections. However, beginning 15 min after the LPBN injections, they were given access to water and 0.3 M NaCl and were allowed to consume the fluids for most of the next 60 min with the free access intake being interrupted only for a few minutes at 15,30 and 60 min after the fluids became available. During each of these three brief periods, a taste reactivity test was conducted. on the three taste reactivity tests rats that received LPBN vehicle injections showed progressive declines in ingestive responses and gradual increases in rejection responses. However, in contrast to the LPBN vehicle treated rats, animals receiving bilateral injections of LPBN moxonidine maintained a high number of ingestive responses and a low number of rejection responses throughout the test period even in spite of evidencing substantial water and 0.3 M NaCl consumption during the periods of free access. The results suggest that after alpha(2)-adrenoceptor agonist delivery to the LPBN the acceptance of 0.3 M NaCl is sustained and the negative attributes of the solution are minimized. The maintained positive rewarding qualities of 0.3 M NaCl are likely to account for why LPBN moxonidine treated rats show such a remarkable salt appetite when assayed by the volume of hypertonic 0.3 M NaCl consumed. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Alfenas, Dept Physiol, Inst Biomed Sci, Unifal MG, BR-37130000 Alfenas, MG, Brazil
dc.description.affiliationUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Iowa, Dept Psychol, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Dept Pharmacol & Hlth, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Dept Human Physiol, Iowa City, IA 52242 USA
dc.description.affiliationUniv Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USA
dc.description.affiliationUnespUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 07/52343-8
dc.description.sponsorshipIdFAPEMIG: APQ-00713-09
dc.description.sponsorshipIdCAPES: 1419-09-9
dc.format.extent702-708
dc.identifierhttp://dx.doi.org/10.1016/j.physbeh.2011.07.020
dc.identifier.citationPhysiology & Behavior. Oxford: Pergamon-Elsevier B.V. Ltd, v. 104, n. 5, p. 702-708, 2011.
dc.identifier.doi10.1016/j.physbeh.2011.07.020
dc.identifier.fileWOS000296208200008.pdf
dc.identifier.issn0031-9384
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16345
dc.identifier.wosWOS:000296208200008
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPhysiology & Behavior
dc.relation.ispartofjcr2.517
dc.relation.ispartofsjr1,088
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPalatabilityen
dc.subjectTasteen
dc.subjectAdrenoceptorsen
dc.subjectThirsten
dc.subjectSodium appetiteen
dc.subjectHindbrainen
dc.titleChanges in taste reactivity to intra-oral hypertonic NaCl after lateral parabrachial injections of an alpha(2)-adrenergic receptor agonisten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes1023597870118105
unesp.author.lattes9055280555067656[1]
unesp.author.orcid0000-0001-8270-2652[3]
unesp.author.orcid0000-0003-1167-4441[5]
unesp.author.orcid0000-0003-3393-2202[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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