Dereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MS

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dc.contributor.authorNeto, Fausto Carnevale [UNESP]
dc.contributor.authorSiquitelli, Cristian D. [UNESP]
dc.contributor.authorPilon, Alan C. [UNESP]
dc.contributor.authorSilva, Dulce H.S. [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorCastro-Gamboa, Ian [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:46Z
dc.date.available2014-05-27T11:29:46Z
dc.date.issued2013-06-20
dc.description.abstractA rational and selective method using on-line high-performance liquid chromatography (HPLC) coupled with electrospray quadrupole time-of-flight tandem mass spectrometry (ESI-QToF-MS/MS) was established for the dereplication of phenolic derivatives from Qualea grandiflora and Qualea cordata. The selection of the extracts was based on the antioxidant capacity measured by in vitro DPPH assay. The HPLC-ESI-QToF-MS/MS analysis was conducted by on-flow detection, using high-resolution mass/ratio ions as well as collision induced MS/MS experiments for selected protonated ions. The dereplication of the EtOAc fraction from the hydro alcohol extract from the stem bark of Q. grandiflora allowed the detection of the flavonoids: 3',4',5',5,6,7-hexahydroxy- 8 methylflavanone, 8-methyl-naringenine and 3',7-dimethoxy-8 methyl-4',5,7- trihydroxyflavanone, as well as a benzophenone derivatives: bis(4,6-dimethoxy-2- hydroxy-3-methylphenyl)- metanone, 3',4'-dimethoxy-8-methyl-5,6,7 trihydroxyflavanone, 7-methoxy-6-methyl- 3',4',5 trihydroxyflavanone, 6,8-dimethyl-3' methoxy-4',5,7 trihydroxyflavanone and 3',5'-dimethoxy-6,8- dimethyl-4',5,7 trihydroxyflavanone were detected in the EtOAc fraction from the hydro-alcohol extract from the leaves of Q. cordata. © 2013 Sociedade Brasileira de Química.en
dc.description.affiliationNucleus of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry São Paulo State University (UNESP), CP 355, 14801-970 Araraquara-SP
dc.description.affiliationUnespNucleus of Bioassay, Biosynthesis and Ecophysiology of Natural Products (NuBBE) Institute of Chemistry São Paulo State University (UNESP), CP 355, 14801-970 Araraquara-SP
dc.format.extent758-764
dc.identifierhttp://dx.doi.org/10.5935/0103-5053.20130098
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 24, n. 5, p. 758-764, 2013.
dc.identifier.doi10.5935/0103-5053.20130098
dc.identifier.file2-s2.0-84879022556.pdf
dc.identifier.issn0103-5053
dc.identifier.issn1678-4790
dc.identifier.lattes4702004904231248
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.scopus2-s2.0-84879022556
dc.identifier.urihttp://hdl.handle.net/11449/75692
dc.identifier.wosWOS:000320468200007
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDereplication
dc.subjectHPLC-ESI-QToF-MS/MS
dc.subjectQualea cordata
dc.subjectQualea grandiflora
dc.subjectRadical scavenging activity
dc.titleDereplication of phenolic derivatives of qualea grandiflora and qualea cordata (vochysiaceae) using liquid chromatography coupled with ESI-QToF-MS/MSen
dc.typeArtigo
dcterms.licensehttp://jbcs.sbq.org.br/copyright
unesp.author.lattes4702004904231248[4]
unesp.author.orcid0000-0002-1516-7765[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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