Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility

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dc.contributor.authorScarel-Caminaga, Raquel M. [UNESP]
dc.contributor.authorKim, Yeon J. [UNESP]
dc.contributor.authorViana, Aline C. [UNESP]
dc.contributor.authorCurtis, Karen M. C. [UNESP]
dc.contributor.authorCorbi, Samia C. T. [UNESP]
dc.contributor.authorSogumo, Patricia M. [UNESP]
dc.contributor.authorOrrico, Silvana Regina Perez [UNESP]
dc.contributor.authorCirelli, Joni Augusto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:31:53Z
dc.date.accessioned2014-05-20T13:45:26Z
dc.date.available2013-09-30T18:31:53Z
dc.date.available2014-05-20T13:45:26Z
dc.date.issued2011-06-01
dc.description.abstractInterleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed together with the previously investigated rs4073 (-251), were associated with chronic periodontitis susceptibility. Clinical periodontal exams were performed and DNA samples were collected from 493 individuals (223 with periodontitis and 270 controls). Associations between SNPs, haplotypes, and subject phenotypes were analyzed using the chi(2) test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians.en
dc.description.affiliationUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 03/10424-0
dc.description.sponsorshipIdFAPESP: 05/03231-7
dc.description.sponsorshipIdFAPESP: 06/04492
dc.format.extent292-302
dc.identifierhttp://dx.doi.org/10.1007/s10528-010-9407-3
dc.identifier.citationBiochemical Genetics. New York: Springer/plenum Publishers, v. 49, n. 5-6, p. 292-302, 2011.
dc.identifier.doi10.1007/s10528-010-9407-3
dc.identifier.issn0006-2928
dc.identifier.lattes7383391319292040
dc.identifier.lattes2628593693450121
dc.identifier.urihttp://hdl.handle.net/11449/15984
dc.identifier.wosWOS:000290537100002
dc.language.isoeng
dc.publisherSpringer/plenum Publishers
dc.relation.ispartofBiochemical Genetics
dc.relation.ispartofjcr1.927
dc.relation.ispartofsjr0,507
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectInterleukin 8en
dc.subjectPeriodontitisen
dc.subjectPolymorphismen
dc.subjectDisease susceptibilityen
dc.titleHaplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibilityen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer/plenum Publishers
unesp.author.lattes7383391319292040
unesp.author.lattes2628593693450121
unesp.author.orcid0000-0002-7082-9290[8]
unesp.author.orcid0000-0002-8235-6072[5]
unesp.author.orcid0000-0001-5068-0268[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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