Different inflammatory stimuli in the footpad of mice influence the kinetics of resident peritoneal cells

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dc.contributor.authorPalos, M. C.
dc.contributor.authorAzevedo, M. C. A.
dc.contributor.authorThies, F. G.
dc.contributor.authorOsugui, L.
dc.contributor.authorAlvares, A. M.
dc.contributor.authorLaurindo, M. F.
dc.contributor.authorRusso, R. T.
dc.contributor.authorPopi, A. F.
dc.contributor.authorMariano, M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-05-20T15:33:44Z
dc.date.available2014-05-20T15:33:44Z
dc.date.issued2012-11-01
dc.description.abstractEvidence from the literature that inflammation is a systemic biological phenomenon prompted us to investigate whether inoculation of different irritants to the footpad of mice might influence the kinetics of resident peritoneal cells.Mice were inoculated in the footpad at different time intervals with Mycobacterium bovis bacillus Calmette-Guerin (BCG), Ehrlich ascitic tumor cells or lipopolysaccharide (LPS), and resident peritoneal cells were analyzed by flow cytometry.The results indicate that different stimuli induced different responses in resident peritoneal cells. FoxP3 positive regulatory T cells increased drastically in number after BCG inoculation. Conversely, tumor cell inoculation induced a decrease in FoxP3-positive T cells in the peritoneal cavity, although this effect was not statistically significant. Results also show that cells from the paw migrate to the popliteal lymph node and to the peritoneal cavity. Yet, there are cells in the peritoneal cavity that migrate to the popliteal lymph node.These data show that cells from the peritoneal cavity are influenced by pathologies in remote regions of the animal. How this novel phenomenon influences overall immune responses, courses of infection and tumor growth are open to further investigation.en
dc.description.affiliationUniv Estadual Paulista, Disciplina Imunol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Disciplina Imunol, BR-04023062 São Paulo, Brazil
dc.description.sponsorshipFACSCanto cytometer
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1187-1194
dc.identifierhttp://dx.doi.org/10.1007/s00011-012-0514-y
dc.identifier.citationInflammation Research. Basel: Springer Basel Ag, v. 61, n. 11, p. 1187-1194, 2012.
dc.identifier.doi10.1007/s00011-012-0514-y
dc.identifier.issn1023-3830
dc.identifier.urihttp://hdl.handle.net/11449/42284
dc.identifier.wosWOS:000309871700003
dc.language.isoeng
dc.publisherSpringer Basel Ag
dc.relation.ispartofInflammation Research
dc.relation.ispartofjcr2.990
dc.relation.ispartofsjr1,062
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectInflammationen
dc.subjectPeritoneumen
dc.subjectEhrlich tumoren
dc.subjectBCGen
dc.subjectLPSen
dc.subjectFoxP3en
dc.titleDifferent inflammatory stimuli in the footpad of mice influence the kinetics of resident peritoneal cellsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer Basel Ag
unesp.author.orcid0000-0001-8899-4182[5]
unesp.author.orcid0000-0001-9814-4181[8]

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