Synthesis of 4-aminoquinoline analogues and their platinum(II) complexes as new antileishmanial and antitubercular agents

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dc.contributor.authorCarmo, Arturene M. L.
dc.contributor.authorSilva, Flavia M. C.
dc.contributor.authorMachado, Patricia A.
dc.contributor.authorFontes, Ana P. S.
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.authorLeite, Sergio R. de A. [UNESP]
dc.contributor.authorCoimbra, Elaine S.
dc.contributor.authorDa Silva, Adilson D.
dc.contributor.institutionUniversidade Federal de Juiz de Fora (UFJF)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:16Z
dc.date.available2014-05-20T13:24:16Z
dc.date.issued2011-06-01
dc.description.abstractA series of 4-amino-7-chloroquinoline derivatives were synthesized by the reaction of 4,7-dichloroquinoline with the corresponding diamine and then with propargyl bromide. In addition, platinum(II) complexes were obtained by reacting some of the organic derivatives with K(2)PtCl(4). Several of the synthesized compounds displayed antituberculosis activities. Compound 3 was 47.5 times more active than amphotericin B against Leishmania chagasi (IC(50) = 0.04 mu g/mL). Compounds 5, 6, 7, 9, 10, 11 and 13 presented promising results against Mycobacterium tuberculosis, with MIC values ranging from 12.5 to 15.6 mu g/mL, comparable to the "first and second line'' drugs used to treat tuberculosis. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv Fed Juiz Fora, Dept Quim, ICE, BR-36036900 Juiz de Fora, MG, Brazil
dc.description.affiliationUniv Fed Juiz Fora, Dept Parasitol Microbiol & Imunol, ICB, BR-36036900 Juiz de Fora, MG, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipBIC/UFJF
dc.description.sponsorshipIdFAPESP: 08/10390-2
dc.description.sponsorshipIdFAPESP: 09/06499-1
dc.format.extent204-209
dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2011.01.003
dc.identifier.citationBiomedicine & Pharmacotherapy. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 65, n. 3, p. 204-209, 2011.
dc.identifier.doi10.1016/j.biopha.2011.01.003
dc.identifier.issn0753-3322
dc.identifier.lattes2114570774349859
dc.identifier.urihttp://hdl.handle.net/11449/7484
dc.identifier.wosWOS:000296960200011
dc.language.isoeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.relation.ispartofjcr3.457
dc.relation.ispartofsjr0,951
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subject4-aminoquinoline analoguesen
dc.subjectPlatinum(II) complexesen
dc.subjectAntileishmanialen
dc.subjectAntitubercularen
dc.subjectLeishmaniaen
dc.subjectMycobacterium tuberculosisen
dc.titleSynthesis of 4-aminoquinoline analogues and their platinum(II) complexes as new antileishmanial and antitubercular agentsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier France-editions Scientifiques Medicales Elsevier
unesp.author.lattes2114570774349859
unesp.author.orcid0000-0002-6969-3963[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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