3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

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dc.contributor.authorRocha, F. V. [UNESP]
dc.contributor.authorBarra, C. V. [UNESP]
dc.contributor.authorNetto, Adelino Vieira de Godoy [UNESP]
dc.contributor.authorMauro, Antonio Eduardo [UNESP]
dc.contributor.authorCarlos, I. Z. [UNESP]
dc.contributor.authorFrem, Regina Célia Galvão [UNESP]
dc.contributor.authorAnanias, S. R. [UNESP]
dc.contributor.authorQuilles, M. B. [UNESP]
dc.contributor.authorStevanato, A. [UNESP]
dc.contributor.authorda Rocha, M. C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:58Z
dc.date.available2014-05-20T13:23:58Z
dc.date.issued2010-05-01
dc.description.abstractComplexes of the type [PdX(2)(tdmPz)] {X = Cl(-)(1) Br(-)(2); l(-)(3); SCN(-)(4); tdmPz = 1-thiocarbamoy1-3,5-dimethylpyrazole} have been synthesized and characterized. Compound 1 was formed from the reaction between [PdCl(2)(CH(3)CN)(2)] and 1-thiocarbamoy1-3,5-dimethylpyrazole. Complexes 2, 3 and 4 were obtained by metathesis of the chloro groups from 1 by bromide, iodide and thiocyanate ions, respectively. All the compounds and cisplatin have been tested in vitro by WIT assay for their cytotoxicity against three murine cancer cell lines: mammary adenocarcinoma (LM3 and LMM3) and lung adenocarcinoma (LP07) as well towards normal murine peritoneal exudate cells (PEC). Promising cytotoxic effect against LM3 has been found for 3 showing IC(50) equal to 24.5 mu M which is comparable to the value obtained for cisplatin (30.3 mu M). (C) 2010 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Quim Geral & Inorgan, Inst Quim Araraquara, UNESP, BR-14801970 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, UNESP, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Quim Geral & Inorgan, Inst Quim Araraquara, UNESP, BR-14801970 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, UNESP, BR-14801902 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1698-1702
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2009.12.073
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 45, n. 5, p. 1698-1702, 2010.
dc.identifier.doi10.1016/j.ejmech.2009.12.073
dc.identifier.issn0223-5234
dc.identifier.lattes3300223970814448
dc.identifier.lattes7927677053650819
dc.identifier.lattes8534138813417161
dc.identifier.orcid0000-0002-0057-7964
dc.identifier.orcid0000-0003-1574-681X
dc.identifier.urihttp://hdl.handle.net/11449/7337
dc.identifier.wosWOS:000276695200002
dc.language.isoeng
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.ispartofjcr4.816
dc.relation.ispartofsjr1,266
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPd(II) complexesen
dc.subject1-Thiocarbamoyl-3,5-dimethylpyrazoleen
dc.subjectSpectroscopyen
dc.subjectAntitumor activityen
dc.title3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activityen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier France-editions Scientifiques Medicales Elsevier
unesp.author.lattes3300223970814448
unesp.author.lattes7927677053650819[3]
unesp.author.lattes8534138813417161[6]
unesp.author.orcid0000-0002-0057-7964[3]
unesp.author.orcid0000-0003-1574-681X[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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