EFFECTS OF LIDOCAINE INJECTIONS INTO THE LATERAL PARABRACHIAL NUCLEUS ON DIPSOGENIC AND PRESSER RESPONSES TO CENTRAL ANGIOTENSIN-II IN RATS

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dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorBeltz, T. G.
dc.contributor.authorJohnson, A. K.
dc.contributor.institutionUNIV IOWA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:25:04Z
dc.date.available2014-05-20T15:25:04Z
dc.date.issued1995-10-16
dc.description.abstractThis study investigated the effects of bilateral injections of the local anesthetic, lidocaine, into the lateral parabrachial nucleus (LPBN) on the dipsogenic and presser responses induced by intracerebroventricular (i.c.v.) injection of angiotensin II (ANG II). Centrally injected ANG II (50 ng/l mu l) induced water intake (10.2 +/- 0.8 ml/h) and presser responses (22 +/- 1 mmHg). Prior bilateral injection of 10% lidocaine (200 nl) into the LPBN increased the water intake (14.2 +/- 1.4 ml/h), but did not change the presser response (17 +/- 1 mmHg) to i.c.v. ANG II. Lidocaine alone injected into the LPBN also induced a presser response (23 +/- 3 mmHg). These results showing that bilateral LPBN injection of lidocaine increase water intake induced by i.c.v. ANG II are consistent with electrolytic and neurotoxic lesion studies and suggest that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II. These results also provide evidence that it is feasible to reversibly anesthetize this brain area to facilitate fluid-related ingestive behavior.en
dc.description.affiliationUNIV IOWA,DEPT PSYCHOL,IOWA CITY,IA 52242
dc.description.affiliationUNIV IOWA,DEPT PHARMACOL,IOWA CITY,IA 52242
dc.description.affiliationUNIV IOWA,CTR CARDIOVASC,IOWA CITY,IA 52242
dc.description.affiliationPAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,BR-14801903 ARARAQUARA,SP,BRAZIL
dc.description.affiliationUnespPAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,BR-14801903 ARARAQUARA,SP,BRAZIL
dc.format.extent250-252
dc.identifierhttp://dx.doi.org/10.1016/0006-8993(95)00872-N
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 695, n. 2, p. 250-252, 1995.
dc.identifier.doi10.1016/0006-8993(95)00872-N
dc.identifier.issn0006-8993
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/35543
dc.identifier.wosWOS:A1995TA39000021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLATERAL PARABRACHIAL NUCLEUSpt
dc.subjectANGIOTENSIN IIpt
dc.subjectWATER INTAKEpt
dc.subjectARTERIAL PRESSUREpt
dc.subjectTHIRSTpt
dc.subjectLOCAL ANESTHETICpt
dc.titleEFFECTS OF LIDOCAINE INJECTIONS INTO THE LATERAL PARABRACHIAL NUCLEUS ON DIPSOGENIC AND PRESSER RESPONSES TO CENTRAL ANGIOTENSIN-II IN RATSen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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