Postweaning exposure to gossypol results in epididymis-specific effects throughout puberty and adulthood in rats

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dc.contributor.authorRomualdo, G. S.
dc.contributor.authorKlinefelter, G. R.
dc.contributor.authorKempinas, W. D.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUS EPA
dc.date.accessioned2014-05-20T15:26:51Z
dc.date.available2014-05-20T15:26:51Z
dc.date.issued2002-03-01
dc.description.abstractGossypol, a yellow pigment found in cottonseeds, well known for its antifertility properties in animals, has been used as a contraceptive by men. The aims of this work were to evaluate the effects of gossypol throughout sexual development of male rats and to provide additional data to clarify the target site or sites of this compound in the male reproductive system, Gossypol (15 mg/kg per day) was given to animals from weaning through prepuberty (41 days), early puberty (51 days), puberty (61 days), and sexual maturity (91 days). Ventral prostate weight and fructose levels were similar in control and treated rats, suggesting that androgen levels were normal. No histological effects on the testis were detected, but there was a significant decrease in the sperm concentration in the cauda epididymidis of gossypol-treated animals killed at 61 and 91 days, as well as a significant increase in abnormal sperm in the vas deferens of treated animals. Moreover, the histology of the cauda epididymidis of the rats treated throughout puberty (ie, until days 51 and 61) showed a great number of round bodies in the lumen of the epididymis. These structures stained for the epididymis-specific protein E. Collectively, the data demonstrate that the epididymis is a target of gossypol when postweaning exposure extends throughout pubertal development, and that whereas more subtle histological effects commence around puberty, indicators reproductive competence are compromised in adulthood.en
dc.description.affiliationState Univ São Paulo, Inst Biosci, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationState Univ São Paulo, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUS EPA, Natl Hlth & Environm Effects Res Lab, Reprod Toxicol Div, Res Triangle Pk, NC 27711 USA
dc.description.affiliationUnespState Univ São Paulo, Inst Biosci, Dept Anat, Botucatu, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.format.extent220-228
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/j.1939-4640.2002.tb02618.x/abstract
dc.identifier.citationJournal of Andrology. Lawrence: Amer Soc Andrology, Inc., v. 23, n. 2, p. 220-228, 2002.
dc.identifier.issn0196-3635
dc.identifier.urihttp://hdl.handle.net/11449/36931
dc.identifier.wosWOS:000173946800011
dc.language.isoeng
dc.publisherAmer Soc Andrology, Inc
dc.relation.ispartofJournal of Andrology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmale reproductionpt
dc.subjectsexual developmentpt
dc.subjectsperm maturationpt
dc.subjectmale contraceptionpt
dc.titlePostweaning exposure to gossypol results in epididymis-specific effects throughout puberty and adulthood in ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderAmer Soc Andrology, Inc
unesp.author.orcid0000-0002-2112-5123[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Anatomia - IBB
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