Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata

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dc.contributor.authorPrince, Karina Andrade de [UNESP]
dc.contributor.authorSordi, Renata [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorSantos, Adolfo Carlos Barreto [UNESP]
dc.contributor.authorAraujo, Angela R. [UNESP]
dc.contributor.authorLeite, Sergio R.A. [UNESP]
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdades Integradas Pitágoras
dc.date.accessioned2014-05-20T13:24:07Z
dc.date.available2014-05-20T13:24:07Z
dc.date.issued2012-03-01
dc.description.abstractOur purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.en
dc.description.affiliationUniversidade Estadual Paulista
dc.description.affiliationFaculdades Integradas Pitágoras
dc.description.affiliationUnespUniversidade Estadual Paulista
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 11/11593-7
dc.description.sponsorshipIdFAPESP: 08/10390-2
dc.description.sponsorshipIdFAPESP: 06/50680
dc.description.sponsorshipIdFAPESP: 09/06499-1
dc.format.extent224-229
dc.identifierhttp://dx.doi.org/10.1590/S1517-83822012000100024
dc.identifier.citationBrazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 43, n. 1, p. 224-229, 2012.
dc.identifier.doi10.1590/S1517-83822012000100024
dc.identifier.fileS1517-83822012000100024.pdf
dc.identifier.issn1517-8382
dc.identifier.lattes2114570774349859
dc.identifier.orcid0000-0001-7616-9652
dc.identifier.scieloS1517-83822012000100024
dc.identifier.urihttp://hdl.handle.net/11449/7403
dc.identifier.wosWOS:000303939800024
dc.language.isoeng
dc.publisherSociedade Brasileira de Microbiologia
dc.relation.ispartofBrazilian Journal of Microbiology
dc.relation.ispartofjcr1.810
dc.relation.ispartofsjr0,630
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectPhomopsis stipataen
dc.subjectantimycobacterial activityen
dc.subjectMycobacterium tuberculosisen
dc.titleAnti-Mycobacterium tuberculosis activity of fungus Phomopsis stipataen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjm/paboutj.htm
unesp.author.lattes2114570774349859
unesp.author.lattes0037579054083160[5]
unesp.author.orcid0000-0001-7616-9652[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Ciências Biológicas - FCFAR