Atrophic Cardiac Remodeling Induced by Taurine Deficiency in Wistar Rats

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dc.contributor.authorPansani, Mariele Castilho [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorMurino Rafacho, Bruna Paola [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorZorzella-Pezavento, Sofia Goncalves [UNESP]
dc.contributor.authorMarchini, Julio Sergio
dc.contributor.authorPadovan, Gilberto Joao
dc.contributor.authorFernandes, Ana Angelica Henrique [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:50:50Z
dc.date.available2014-05-20T13:50:50Z
dc.date.issued2012-07-23
dc.description.abstractIntroduction: Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.Methods: Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. on day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.Results: Taurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T () rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.Conclusions: These data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics.en
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Internal Med, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Chem & Biochem, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFaculdade de Medicina de Botucatu - UNESP
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0041439
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 7, n. 7, p. 6, 2012.
dc.identifier.doi10.1371/journal.pone.0041439
dc.identifier.fileWOS000306687700090.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes6990977122340795
dc.identifier.lattes6309835137998766
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.urihttp://hdl.handle.net/11449/18143
dc.identifier.wosWOS:000306687700090
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPLOS ONE
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleAtrophic Cardiac Remodeling Induced by Taurine Deficiency in Wistar Ratsen
dc.typeArtigo
dcterms.licensehttp://www.plos.org/about/open-access/license/
dcterms.rightsHolderPublic Library Science
unesp.author.lattes5016839015394547[13]
unesp.author.lattes6990977122340795
unesp.author.lattes6309835137998766
unesp.author.lattes1213140801402647[2]
unesp.author.lattes7438704034471673
unesp.author.orcid0000-0001-9999-9149[7]
unesp.author.orcid0000-0001-9030-0768[6]
unesp.author.orcid0000-0002-5980-4367[4]
unesp.author.orcid0000-0001-8825-6980[3]
unesp.author.orcid0000-0003-4412-1990[13]
unesp.author.orcid0000-0002-5843-6232[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Clínica Médica - FMB
Artigos - Microbiologia e Imunologia - IBB
Artigos - Química e Bioquímica - IBB