Comparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma

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dc.contributor.authorde Sousa, Fernando-Augusto-Cervantes-Garcia [UNESP]
dc.contributor.authorParadella, Thais-Cachute [UNESP]
dc.contributor.authorCarvalho, Yasmin-Rodarte [UNESP]
dc.contributor.authorRosa, Luiz-Eduardo-Blumer [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:33Z
dc.date.available2014-05-20T14:04:33Z
dc.date.issued2009-11-01
dc.description.abstractBackground: Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. Aim: To evaluate the cell proliferation rate in oral lichen planus, comparing it to the rate observed in epithelial dysplasia and oral squamous cell carcinoma, aiming at indications which might indicate the potential for malignant transformation. Material and Methods: Twenty-four cases of each lesion were submitted to the streptoavidin-biotin and AgNOR technique to evaluate the immunohistochemical expression of PCNA and the mean NORs/ nucleus, respectively. Results: Positivity for PCNA was observed in 58.33% of oral lichen planus cases, 83.33% of epithelial dysplasia cases and 91.67% of oral squamous cell carcinoma cases. Chi-squared test showed that the number of positive cases for PCNA was significantly lower in oral lichen planus than in oral squamous cell carcinoma (p<0.05). No significant statistical difference between oral lichen planus and epithelial dysplasia (p>0.05) and between the epithelial dysplasia and oral squamous cell carcinoma (p>0.05) was observed. The mean NORs/ nucleus in oral lichen planus, epithelial dysplasia and oral squamous cell carcinoma were 1.74 +/- 0.32, 2.42 +/- 0.62 e 2.41 +/- 0.61, respectively. Variance analysis (ANOVA) revealed significant statistical difference between oral lichen planus and the other studied lesions (p<0.05). Conclusion: Oral lichen planus cell proliferation rate was less than in oral epithelial dysplasia and oral squamous cell carcinoma which might explain the lower malignant transformation rate.en
dc.description.affiliationSão Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil
dc.format.extentE563-E567
dc.identifierhttp://dx.doi.org/10.4317/medoral.14.e563
dc.identifier.citationMedicina Oral Patologia Oral Y Cirugia Bucal. Valencia: Medicina Oral S L, v. 14, n. 11, p. E563-E567, 2009.
dc.identifier.doi10.4317/medoral.14.e563
dc.identifier.issn1698-4447
dc.identifier.urihttp://hdl.handle.net/11449/22649
dc.identifier.wosWOS:000273829300002
dc.language.isoeng
dc.publisherMedicina Oral S L
dc.relation.ispartofMedicina Oral Patologia Oral y Cirugia Bucal
dc.relation.ispartofsjr0,841
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectOral lichen planusen
dc.subjectepithelial dysplasiaen
dc.subjectoral squamous cell carcinomaen
dc.subjectimmunohistochemistryen
dc.subjectAgnoren
dc.titleComparative analysis of cell proliferation ratio in oral lichen planus, epithelial dysplasia and oral squamous cell carcinomaen
dc.typeArtigo
dcterms.licensehttp://scielo.isciii.es/revistas/medicor/eaboutj.htm
dcterms.rightsHolderMedicina Oral S L
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Biociências e Diagnóstico Bucal - ICT