Association of ABO gene mutations resulting in a rare B subgroup

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dc.contributor.authorSousa, N.
dc.contributor.authorAnicchino-Bizzacchi, J. M.
dc.contributor.authorLeite, E. M.
dc.contributor.authorLocatelli, M. F.
dc.contributor.authorAlbuquerque, D.
dc.contributor.authorCosta, F. F.
dc.contributor.authorCastro, M. L.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:25Z
dc.date.available2014-05-20T13:24:25Z
dc.date.issued2005-01-01
dc.description.abstractBackground and Objectives B subgroups are rare and the genetic analysis reported to date has been limited.Materials and Methods Serological and molecular investigations were performed in blood from a B-subgroup donor.Results Red cells did not react with anti-B and anti-AB reagents. However, cells absorbed anti-B. Red cells presented positive reactions with anti-H, and saliva secreted H substance. The molecular study demonstrated a B allele with the substitutions 467C>T, 646T>A, 681G>A, 771C>T, 796C>A, 803G>C, 829G>A and an 0 allele with the sequence of 002.Conclusions It is probable that the presence in exon 7 of some of the 002 substitutions could have weakened the enzymatic activity of the encoded B transferase.en
dc.description.affiliationUniv Estadual Campinas, Hemoctr, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, FCM, Dept Farmacol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Araraquara, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Araraquara, Brazil
dc.format.extent31-34
dc.identifierhttp://dx.doi.org/10.1111/j.1423-0410.2005.00583.x
dc.identifier.citationVox Sanguinis. Oxford: Blackwell Publishing Ltd, v. 88, n. 1, p. 31-34, 2005.
dc.identifier.doi10.1111/j.1423-0410.2005.00583.x
dc.identifier.issn0042-9007
dc.identifier.urihttp://hdl.handle.net/11449/7561
dc.identifier.wosWOS:000226931200005
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofVox Sanguinis
dc.relation.ispartofjcr2.107
dc.relation.ispartofsjr1,003
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectABOpt
dc.subjectB subgrouppt
dc.subjectblood grouppt
dc.subjectgenotypingpt
dc.subjectmolecular biologypt
dc.titleAssociation of ABO gene mutations resulting in a rare B subgroupen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing Ltd

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