Inorganic-Organic Nanocomposite Assembly Using Collagen as a Template and Sodium Tripolyphosphate as a Biomimetic Analog of Matrix Phosphoprotein

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dc.contributor.authorDai, Lin
dc.contributor.authorQi, Yi-Pin
dc.contributor.authorNiu, Li-Na
dc.contributor.authorLiu, Yan
dc.contributor.authorPucci, Cesar R. [UNESP]
dc.contributor.authorLooney, Stephen W.
dc.contributor.authorLing, Jun-Qi
dc.contributor.authorPashley, David H.
dc.contributor.authorTay, Franklin R.
dc.contributor.institutionSun Yat Sen Univ
dc.contributor.institutionFirst Hosp Wuhan
dc.contributor.institutionFourth Mil Med Univ
dc.contributor.institutionPeking Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionGeorgia Hlth Sci Univ
dc.date.accessioned2014-05-20T15:32:10Z
dc.date.available2014-05-20T15:32:10Z
dc.date.issued2011-08-01
dc.description.abstractNanocomposites created with polycarboxylic acid alone as a stabilization agent for prenucleation clusters-derived amorphous calcium phosphate exhibit nonperiodic apatite deposition. In the present study, we report the use of inorganic polyphosphate as a biomimetic analog of matrix phosphoprotein for directing poly(acrylic acid)-stabilized amorphous nano-precursor phases to assemble into periodic apatite-collagen nanocomposites. The sorption and desorption characteristics of sodium tripolyphosphate to type I collagen were examined. Periodic nanocomposite assembly with collagen as a template was demonstrated with TEM and SEM using a Portland cement-based resin composite and a phosphate-containing simulated body fluid. Apatite was detected within the collagen at 24 h and became more distinct at 48 h, with prenucleation clusters attaching to the collagen fibril surface during the initial infiltration stage. Apatite-collagen nanocomposites at 72 h were heavily mineralized with periodically arranged intrafibrillar apatite platelets. Defect-containing nanocomposites caused by desorption of TPP from collagen fibrils were observed in regions lacking the inorganic phase.en
dc.description.affiliationSun Yat Sen Univ, Dept Operat Dent & Endodont, Guanghua Sch Stomatol, Guangzhou 510275, Guangdong, Peoples R China
dc.description.affiliationFirst Hosp Wuhan, Dept Stomatol, Wuhan, Peoples R China
dc.description.affiliationFourth Mil Med Univ, Dept Prosthodont, Sch Stomatol, Xian 710032, Peoples R China
dc.description.affiliationPeking Univ, Dept Orthodont, Sch Stomatol, Beijing 100871, Peoples R China
dc.description.affiliationUniv Estadual Paulista, Fac Odontol Sao Jose de Campos, UNESP, São Paulo, Brazil
dc.description.affiliationGeorgia Hlth Sci Univ, Dept Biostat, Augusta, GA 30912 USA
dc.description.affiliationGeorgia Hlth Sci Univ, Dept Oral Biol, Augusta, GA 30912 USA
dc.description.affiliationGeorgia Hlth Sci Univ, Dept Endodont, Augusta, GA 30912 USA
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol Sao Jose de Campos, UNESP, São Paulo, Brazil
dc.description.sponsorshipNIDCR
dc.description.sponsorshipGeorgia Health Sciences University
dc.description.sponsorshipIdNIDCR: R21 DE019213
dc.format.extent3504-3511
dc.identifierhttp://dx.doi.org/10.1021/cg200663v
dc.identifier.citationCrystal Growth & Design. Washington: Amer Chemical Soc, v. 11, n. 8, p. 3504-3511, 2011.
dc.identifier.doi10.1021/cg200663v
dc.identifier.issn1528-7483
dc.identifier.lattes1754020652874850
dc.identifier.orcid0000-0003-4830-0400
dc.identifier.urihttp://hdl.handle.net/11449/41139
dc.identifier.wosWOS:000293356400025
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofCrystal Growth & Design
dc.relation.ispartofjcr3.972
dc.relation.ispartofsjr1,154
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleInorganic-Organic Nanocomposite Assembly Using Collagen as a Template and Sodium Tripolyphosphate as a Biomimetic Analog of Matrix Phosphoproteinen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/copyright/journals/faqs.html
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes1754020652874850[5]
unesp.author.orcid0000-0003-4830-0400[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Odontologia Restauradora - ICT